用于诊断神经退行性疾病的计算生物学进展:全面综述》。

N G Raghavendra Rao, Gurinderdeep Singh, Arvind R Bhagat Patil, T Naga Aparna, Shanmugam Vippamakula, Sudhahar Dharmalingam, D Kumarasamyraja, Vinod Kumar
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引用次数: 0

摘要

神经退行性疾病种类繁多,形式各异,给当代医疗保健带来了巨大挑战。人工智能的出现从根本上改变了诊断方法,它提供了识别这些致残疾病的有效早期手段。作为计算智能的一个子集,机器学习算法已成为分析包括基因、成像和临床数据在内的大型数据集的非常有效的工具。此外,多模式数据整合(包括脑成像(核磁共振成像、正电子发射计算机断层扫描)、基因图谱和临床评估信息)也因计算智能而变得更加容易。通过这种整合方法,可以全面了解疾病的过程,也有助于创建预测模型,进行早期医疗评估和结果预测。此外,将人工智能用于神经影像分析也大有可为。先进的图像处理方法与机器学习算法相结合,使识别大脑功能和结构异常成为可能,而这些异常往往是神经退行性疾病的早期指标。本章将探讨计算智能如何在改善帕金森氏症、阿尔茨海默氏症等神经退行性疾病的诊断中发挥关键作用。总之,计算智能为改善神经退行性疾病的识别提供了一种革命性的方法。在与这些疑难杂症的斗争中,接受并改进这些计算技术必将为更多个性化疗法和更多成功疗法铺平道路。
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Advances in Computational Biology for Diagnosing Neurodegenerative Diseases: A Comprehensive Review.

The numerous and varied forms of neurodegenerative illnesses provide a considerable challenge to contemporary healthcare. The emergence of artificial intelligence has fundamentally changed the diagnostic picture by providing effective and early means of identifying these crippling illnesses. As a subset of computational intelligence, machine-learning algorithms have become very effective tools for the analysis of large datasets that include genetic, imaging, and clinical data. Moreover, multi-modal data integration, which includes information from brain imaging (MRI, PET scans), genetic profiles, and clinical evaluations, is made easier by computational intelligence. A thorough knowledge of the course of the illness is made possible by this consolidative method, which also facilitates the creation of predictive models for early medical evaluation and outcome prediction. Furthermore, there has been a great deal of promise shown by the use of artificial intelligence to neuroimaging analysis. Sophisticated image processing methods combined with machine learning algorithms make it possible to identify functional and structural anomalies in the brain, which often act as early indicators of neurodegenerative diseases. This chapter examines how computational intelligence plays a critical role in improving the diagnosis of neurodegenerative diseases such as Parkinson's, Alzheimer's, etc. To sum up, computational intelligence provides a revolutionary approach for improving the identification of neurodegenerative illnesses. In the battle against these difficult disorders, embracing and improving these computational techniques will surely pave the path for more individualized therapy and more therapies that are successful.

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