{"title":"基于尿烷的第 1-5 层树枝的迭代点击添加过程","authors":"Syunya Inayama, and , Shotaro Hayashi*, ","doi":"10.1021/acsapm.4c01618","DOIUrl":null,"url":null,"abstract":"<p >Dendrimers and dendrons are widely studied in the industrial and academic fields, but their efficient synthesis remains challenging. We herein report the synthesis of a type of urethane-based dendron through a facile, tailor-made, iterative click-addition process (iCAP). Hydroxyl-group-terminated first–5th generation dendrons were synthesized through iCAP, in which nucleophilic urethane and thiol–ene addition reactions were repeated alternately. <sup>1</sup>H NMR spectroscopic and SEC measurements showed that each reaction progressed quantitatively at all stages. Because iCAP involves only two types of addition reactions, it is different from conventional polyurethane-type dendrimer and dendron syntheses in that it has high atom utilization efficiency. In addition to the iCAP to first–5th generation dendrons, the urethane-forming addition reaction to the terminal hydroxyl group also proceeded quantitatively, giving dendrons having long alkyl chain termini. Differential scanning calorimetry measurements showed that the thermophysical properties of the dendrons changed as the number of generations increased. Additionally, when we investigated the aggregation of the dendrons by scanning electron microscopy images of the solution-growth solids, unique morphologies were observed. It is expected that by expanding this synthetic process, we will be able to design and synthesize a variety of topological sequence-defined polymers and impart them with a wide variety of polymer functionalities.</p>","PeriodicalId":7,"journal":{"name":"ACS Applied Polymer Materials","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Iterative Click-Addition Process for Urethane-based 1st-5th Dendrons\",\"authors\":\"Syunya Inayama, and , Shotaro Hayashi*, \",\"doi\":\"10.1021/acsapm.4c01618\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Dendrimers and dendrons are widely studied in the industrial and academic fields, but their efficient synthesis remains challenging. We herein report the synthesis of a type of urethane-based dendron through a facile, tailor-made, iterative click-addition process (iCAP). Hydroxyl-group-terminated first–5th generation dendrons were synthesized through iCAP, in which nucleophilic urethane and thiol–ene addition reactions were repeated alternately. <sup>1</sup>H NMR spectroscopic and SEC measurements showed that each reaction progressed quantitatively at all stages. Because iCAP involves only two types of addition reactions, it is different from conventional polyurethane-type dendrimer and dendron syntheses in that it has high atom utilization efficiency. In addition to the iCAP to first–5th generation dendrons, the urethane-forming addition reaction to the terminal hydroxyl group also proceeded quantitatively, giving dendrons having long alkyl chain termini. Differential scanning calorimetry measurements showed that the thermophysical properties of the dendrons changed as the number of generations increased. Additionally, when we investigated the aggregation of the dendrons by scanning electron microscopy images of the solution-growth solids, unique morphologies were observed. It is expected that by expanding this synthetic process, we will be able to design and synthesize a variety of topological sequence-defined polymers and impart them with a wide variety of polymer functionalities.</p>\",\"PeriodicalId\":7,\"journal\":{\"name\":\"ACS Applied Polymer Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Polymer Materials\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsapm.4c01618\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Polymer Materials","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsapm.4c01618","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Iterative Click-Addition Process for Urethane-based 1st-5th Dendrons
Dendrimers and dendrons are widely studied in the industrial and academic fields, but their efficient synthesis remains challenging. We herein report the synthesis of a type of urethane-based dendron through a facile, tailor-made, iterative click-addition process (iCAP). Hydroxyl-group-terminated first–5th generation dendrons were synthesized through iCAP, in which nucleophilic urethane and thiol–ene addition reactions were repeated alternately. 1H NMR spectroscopic and SEC measurements showed that each reaction progressed quantitatively at all stages. Because iCAP involves only two types of addition reactions, it is different from conventional polyurethane-type dendrimer and dendron syntheses in that it has high atom utilization efficiency. In addition to the iCAP to first–5th generation dendrons, the urethane-forming addition reaction to the terminal hydroxyl group also proceeded quantitatively, giving dendrons having long alkyl chain termini. Differential scanning calorimetry measurements showed that the thermophysical properties of the dendrons changed as the number of generations increased. Additionally, when we investigated the aggregation of the dendrons by scanning electron microscopy images of the solution-growth solids, unique morphologies were observed. It is expected that by expanding this synthetic process, we will be able to design and synthesize a variety of topological sequence-defined polymers and impart them with a wide variety of polymer functionalities.
期刊介绍:
ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.