ETS2 调节 IBD 中的人类炎症巨噬细胞

IF 45.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-02 DOI:10.1038/s41575-024-00960-x
Katrina Ray
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引用次数: 0

摘要

最新研究发现,ETS2 是人类炎症巨噬细胞的核心调节因子。研究人员对 chr21q22 上的一个基因间区域(所谓的基因荒漠)进行了调查,该区域与一系列炎症性疾病有关,包括炎症性肠病(IBD)、强直性脊柱炎、原发性硬化性胆管炎和高安动脉炎。一系列实验发现,ETS2(一种 ETS 家族转录因子和原癌基因)是控制和协调人类炎症巨噬细胞及炎症效应的核心。受 ETS2 调控的基因在患病组织中高度表达,与其他通路相比,ETS2 在 IBD 全基因组关联研究中的命中率更高。重要的是,ETS2 在体外静息人类巨噬细胞中的过表达再现了在 chr21q22 相关疾病(如 IBD)中观察到的炎症状态。最后,研究人员证明,可以通过抑制体外巨噬细胞中的 MEK1/2 和体外培养的活动性 IBD 患者肠活检样本中的 MEK1/2 来抑制 ETS2 信号和炎症。
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ETS2 regulates human inflammatory macrophages in IBD
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来源期刊
CiteScore
52.30
自引率
0.60%
发文量
147
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.
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