BCAA 代谢在代谢健康和疾病中的作用。

IF 9.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Experimental and Molecular Medicine Pub Date : 2024-07-02 DOI:10.1038/s12276-024-01263-6
Byeong Hun Choi, Seunghoon Hyun, Seung-Hoi Koo
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引用次数: 0

摘要

长期以来,人们一直认为限制饮食有利于确保哺乳动物(包括人类)长寿并延长其健康寿命。特别是,蛋白质摄入量的减少已被证明与饮食限制对代谢紊乱的有益影响有特别联系,这可能是通过降低雷帕霉素机理靶点复合体(mTORC)1的活性以及AMP激活蛋白激酶(AMPK)和sirtuin通路的相互激活来实现的。尽管支链氨基酸被广泛用作延缓人类衰老的膳食补充剂,但最近的证据表明,支链氨基酸可能是导致蛋白质膳食对衰老和相关疾病产生不良影响的主要原因。在这篇综述中,我们将从组织特异性水平上描述支链氨基酸代谢途径的调控,并总结有关支链氨基酸在控制哺乳动物代谢健康和疾病方面作用的最新发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The role of BCAA metabolism in metabolic health and disease
It has long been postulated that dietary restriction is beneficial for ensuring longevity and extending the health span of mammals, including humans. In particular, a reduction in protein consumption has been shown to be specifically linked to the beneficial effect of dietary restriction on metabolic disorders, presumably by reducing the activity of the mechanistic target of rapamycin complex (mTORC) 1 and the reciprocal activation of AMP-activated protein kinase (AMPK) and sirtuin pathways. Although it is widely used as a dietary supplement to delay the aging process in humans, recent evidence suggests that branched-chain amino acids (BCAAs) might be a major cause of the deteriorating effect of a protein diet on aging and related disorders. In this review, we delineate the regulation of metabolic pathways for BCAAs at the tissue-specific level and summarize recent findings regarding the role of BCAAs in the control of metabolic health and disease in mammals. This review article illustrates the function of branched-chain amino acids (BCAAs - essential nutrients we get from food) and how they’re processed in our bodies, in relation to health and illness. BCAAs are connected to aging processes and metabolic health - the body’s way of converting food into energy. Recent studies found that reducing BCAA intake can improve the health and lifespan of rodents. Similar studies were also conducted by using different animal models, like yeast, flies, rodents, and primates. It also emphasized the potential influence of BCAAs on human disease and aging metabolic processes. The review article concluded that BCAAs and their processing are vital for metabolic health and lifespan, and more research is needed to understand their effect on human health. Further studies on BCAAs could be important for creating diet plans and treatments for metabolic issues and aging-related diseases. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
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来源期刊
Experimental and Molecular Medicine
Experimental and Molecular Medicine 医学-生化与分子生物学
CiteScore
19.50
自引率
0.80%
发文量
166
审稿时长
3 months
期刊介绍: Experimental & Molecular Medicine (EMM) stands as Korea's pioneering biochemistry journal, established in 1964 and rejuvenated in 1996 as an Open Access, fully peer-reviewed international journal. Dedicated to advancing translational research and showcasing recent breakthroughs in the biomedical realm, EMM invites submissions encompassing genetic, molecular, and cellular studies of human physiology and diseases. Emphasizing the correlation between experimental and translational research and enhanced clinical benefits, the journal actively encourages contributions employing specific molecular tools. Welcoming studies that bridge basic discoveries with clinical relevance, alongside articles demonstrating clear in vivo significance and novelty, Experimental & Molecular Medicine proudly serves as an open-access, online-only repository of cutting-edge medical research.
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