未成熟血小板比例与急性冠状动脉综合征;系统综述与 Meta 分析》。

IF 2.9 Q1 EMERGENCY MEDICINE Archives of Academic Emergency Medicine Pub Date : 2024-04-23 eCollection Date: 2024-01-01 DOI:10.22037/aaem.v12i1.2292
Elmira Jafari Afshar, Vahid Shahnavaz, Hamed Talakoob, Parnaz Kafialqora, Aryan Madady, Shamimeh Pourbahrighesmat, Amirhossein Tayebi, Mohammadhossein MozafaryBazargany, Niloofar Gholami, Aryan Ayati, Parham Samimisedeh, Hadith Rastad, Hossein Karim
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引用次数: 0

摘要

简介:未成熟血小板比率(IPF)是衡量循环中网状血小板(RP)占所有血小板比例的指标。IPF 对急性冠状动脉综合征(ACS)患者可能具有预后和诊断价值。本研究旨在全面总结 IPF 水平在 ACS 患者中的诊断效用,尤其关注其区分 ACS 不同亚型的能力:我们对截至 2024 年 3 月 4 日的在线数据库(包括 MEDLINE、Scopus 和 Google Scholar)进行了系统检索,以确定相关研究。我们采用随机效应模型、均值差异(MD)逆方差法和曼特尔-海恩泽尔(Mantel-Haenszel)几率比(OR)法来合并数据。乔安娜-布里格斯研究所(JBI)的评估工具用于评估纳入研究的质量:我们的系统综述包含 15 篇文章,样本量共计 2,030 例 ACS 患者。汇总分析显示,与健康对照组(MD (95%CI): 2.85 (0.86, 4.85), P-value = 0.004)和稳定型心绞痛患者(MD (95%CI): 0.58 (0.23, 0.92), P-value < 0.001)相比,ACS 患者的 IPF 水平存在显著差异。对 ACS 患者进行的亚组比较显示,心肌梗死(MI)与不稳定型心绞痛(UA)患者的 IPF 水平更高(MD (95%CI): 1.81 (0.41, 3.22),P 值 = 0.01)、ST段抬高型心肌梗死(STEMI)与非ST段抬高型心肌梗死(NSTEMI)ACS(MD(95%CI):0.74(0.31,1.17),P值<0.001)和NSTEMI与UA(MD(95%CI):1.07(0.24,1.90),P值=0.01):ACS患者的IPF水平可能升高,尤其是在STEMI的急性期。这表明 IPF 可能是早期诊断 ACS 的有用生物标志物。此外,IPF水平还有助于区分ACS亚型。
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Immature Platelet Fraction and Acute Coronary Syndrome; a Systematic Review and Meta-Analysis.

Introduction: Immature Platelet Fraction (IPF) is a measure of the proportion of reticulated platelets (RPs) to all platelets in circulation. IPF may have both prognostic and diagnostic values in patients with Acute Coronary Syndrome (ACS). This study aims to comprehensively summarize the diagnostic utility of IPF levels in patients with ACS, specifically focusing on its ability to differentiate between different subtypes of ACS.

Methods: We conducted a systematic search in online databases including MEDLINE, Scopus, and Google Scholar up to March 4th 2024, to identify relevant studies. The random-effect model, employing inverse variance for mean differences (MD) and Mantel-Haenszel methods for odds ratios (OR) were utilized to combine the data. Joanna Briggs Institute (JBI) appraisal tool was employed to assess the quality of included studies.

Results: Our systematic review contains 15 articles with a total sample size of 2,030 ACS patients. Pooled analysis revealed significant differences in IPF levels of ACS patients compared to healthy controls (MD (95%CI): 2.85 (0.86, 4.85), P-value = 0.004) and stable angina patients (MD (95%CI): 0.58 (0.23, 0.92), P-value < 0.001). Subgroup comparisons within ACS patients demonstrated higher IPF levels in myocardial infarction (MI) vs. unstable angina (UA) (MD (95%CI): 1.81 (0.41, 3.22), P-value = 0.01), ST elevation MI (STEMI) vs. non-ST elevation (NSTEMI) ACS (MD (95%CI): 0.74 (0.31, 1.17), P-value < 0.001), and NSTEMI vs. UA (MD (95% CI): 1.07 (0.24, 1.90), P-value = 0.01).

Conclusion: IPF levels could increase in patients with ACS, particularly during the acute phase of STEMI. This suggests that IPF may be a useful biomarker for early diagnosis of ACS. Additionally, IPF levels may help differentiate between ACS subtypes.

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来源期刊
Archives of Academic Emergency Medicine
Archives of Academic Emergency Medicine Medicine-Emergency Medicine
CiteScore
8.90
自引率
7.40%
发文量
0
审稿时长
6 weeks
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