用于检测超氧化物的有机硒基喹啉传感器及其抗肿瘤活性

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Chemical Sciences Pub Date : 2024-06-20 DOI:10.1007/s12039-024-02276-4

Shrikrishna T Salunke, Divyesh S Shelar, Snehal S Salunkhe, Pinky R Singh, Shashikant P Vaidya, Sudesh T Manjare

{"title":"用于检测超氧化物的有机硒基喹啉传感器及其抗肿瘤活性","authors":"Shrikrishna T Salunke, Divyesh S Shelar, Snehal S Salunkhe, Pinky R Singh, Shashikant P Vaidya, Sudesh T Manjare","doi":"10.1007/s12039-024-02276-4","DOIUrl":null,"url":null,"abstract":"<p>Quinoline-based “turn-on” fluorescent probe was successfully synthesized using 5-amino quinoline and 2-(phenylselanyl)benzaldehyde. The probe was found to be selective for superoxide over other reactive oxygen species (ROS) and biothiols. The probe can detect superoxide in the presence of other ROS and biothiols. The detection limit of the probe for superoxide was found to be 37 nM with a Stokes shift of 150 nm. The probe quickly detects superoxide with a 21-fold increase in fluorescence intensity. The probe exhibited anticancer activity on HeLa cells that was comparable to the standard drug (Cisplatin).</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3><p>Organoselenium based quinoline probe was developed. The probe was selective for superoxide with instant response and possess good anticancer activity.\n</p>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Organoselenium-based quinoline sensor for superoxide detection and its antitumor activities\",\"authors\":\"Shrikrishna T Salunke, Divyesh S Shelar, Snehal S Salunkhe, Pinky R Singh, Shashikant P Vaidya, Sudesh T Manjare\",\"doi\":\"10.1007/s12039-024-02276-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Quinoline-based “turn-on” fluorescent probe was successfully synthesized using 5-amino quinoline and 2-(phenylselanyl)benzaldehyde. The probe was found to be selective for superoxide over other reactive oxygen species (ROS) and biothiols. The probe can detect superoxide in the presence of other ROS and biothiols. The detection limit of the probe for superoxide was found to be 37 nM with a Stokes shift of 150 nm. The probe quickly detects superoxide with a 21-fold increase in fluorescence intensity. The probe exhibited anticancer activity on HeLa cells that was comparable to the standard drug (Cisplatin).</p><h3 data-test=\\\"abstract-sub-heading\\\">Graphical abstract</h3><p>Organoselenium based quinoline probe was developed. The probe was selective for superoxide with instant response and possess good anticancer activity.\\n</p>\",\"PeriodicalId\":616,\"journal\":{\"name\":\"Journal of Chemical Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Chemical Sciences\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s12039-024-02276-4\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical Sciences","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s12039-024-02276-4","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

利用 5-氨基喹啉和 2-（苯基苯丙氨酰）苯甲醛成功合成了基于喹啉的 "开启 "荧光探针。研究发现，该探针对超氧化物具有选择性，而对其他活性氧（ROS）和生物硫醇则没有选择性。该探针可以在存在其他活性氧和生物硫醇的情况下检测超氧化物。探针对超氧化物的检测限为 37 nM，斯托克斯位移为 150 nm。该探针能快速检测到超氧化物，荧光强度增加了 21 倍。该探针对 HeLa 细胞的抗癌活性与标准药物（顺铂）相当。该探针对超氧化物具有选择性，反应迅速，并具有良好的抗癌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Organoselenium-based quinoline sensor for superoxide detection and its antitumor activities

Quinoline-based “turn-on” fluorescent probe was successfully synthesized using 5-amino quinoline and 2-(phenylselanyl)benzaldehyde. The probe was found to be selective for superoxide over other reactive oxygen species (ROS) and biothiols. The probe can detect superoxide in the presence of other ROS and biothiols. The detection limit of the probe for superoxide was found to be 37 nM with a Stokes shift of 150 nm. The probe quickly detects superoxide with a 21-fold increase in fluorescence intensity. The probe exhibited anticancer activity on HeLa cells that was comparable to the standard drug (Cisplatin).

Graphical abstract

Organoselenium based quinoline probe was developed. The probe was selective for superoxide with instant response and possess good anticancer activity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.