设计和制备四组分共晶凝胶,作为无溶剂条件下单锅多组分合成 1,2,4,5- 四取代咪唑和 2,4,5- 三取代咪唑衍生物的绿色高效催化剂

IF 3.4 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Reaction Chemistry & Engineering Pub Date : 2024-06-14 DOI:10.1039/D4RE00169A
Phat Ngoc Nguyen, Trung-Nhan Dong Tran, Nhat Minh Nguyen, Viet-Hoang Nguyen Le, Linh Dieu Nguyen, Phuong Hoang Tran and Hai Truong Nguyen
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引用次数: 0

摘要

在过去几年中,在合成有机化学中对咪唑衍生物合成的探索出现了显著的增长。这种日益增长的兴趣源于这些化合物在工业化学、医药和药物化学等各个领域的广泛潜在应用。本研究展示了四组分共晶凝胶(ETG),特别是 ETG-Zr4+,用于生产咪唑衍生物的创新合成方法。利用傅立叶变换红外光谱、扫描电子显微镜、热重分析和 XRD 对 ETG-Zr4+ 催化剂进行了表征,证明了其作为一种可持续催化剂合成多官能化咪唑衍生物的潜力。使用 ETG-Zr4+ 作为催化剂合成 1,2,4,5-四苯基-1H-咪唑衍生物的产率为 70-92%,合成 2,4,5-三取代咪唑衍生物的产率为 61-76%。值得注意的是,该催化剂具有可重复使用的优势,并通过一锅多组分反应途径促进了环保方法的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Design and preparation of four-component eutectogels as a green and efficient catalyst for the one-pot multi-component synthesis of 1,2,4,5-tetrasubstituted and 2,4,5-trisubstituted imidazole derivatives under solvent-free conditions†

In the past few years, there has been a prominent surge in the exploration of the synthesis of imidazole derivatives in synthetic organic chemistry. This growing interest arises from the wide range of potential applications offered by these compounds across various fields, encompassing industrial chemistry, pharmaceuticals, and medicinal chemistry. This study demonstrates an innovative synthesis of four-component eutectogels (ETGs), in particular ETG-Zr4+, for the production of imidazole derivatives. The ETG-Zr4+ catalyst was characterized using FT-IR spectroscopy, SEM, TGA, and XRD, demonstrating its potential as a sustainable catalyst for the synthesis of poly-functionalized imidazole derivatives. The application of ETG-Zr4+ as a catalyst afforded 1,2,4,5-tetraphenyl-1H-imidazole derivatives in 70–92% yields and 2,4,5-trisubstituted imidazole derivatives in 61–76% yields. Notably, the catalyst exhibits the advantage of reusability and promotes eco-friendly approaches via a one-pot, multi-component reaction pathway.

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来源期刊
Reaction Chemistry & Engineering
Reaction Chemistry & Engineering Chemistry-Chemistry (miscellaneous)
CiteScore
6.60
自引率
7.70%
发文量
227
期刊介绍: Reaction Chemistry & Engineering is a new journal reporting cutting edge research into all aspects of making molecules for the benefit of fundamental research, applied processes and wider society. From fundamental, molecular-level chemistry to large scale chemical production, Reaction Chemistry & Engineering brings together communities of chemists and chemical engineers working to ensure the crucial role of reaction chemistry in today’s world.
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