Phat Ngoc Nguyen, Trung-Nhan Dong Tran, Nhat Minh Nguyen, Viet-Hoang Nguyen Le, Linh Dieu Nguyen, Phuong Hoang Tran and Hai Truong Nguyen
{"title":"设计和制备四组分共晶凝胶,作为无溶剂条件下单锅多组分合成 1,2,4,5- 四取代咪唑和 2,4,5- 三取代咪唑衍生物的绿色高效催化剂","authors":"Phat Ngoc Nguyen, Trung-Nhan Dong Tran, Nhat Minh Nguyen, Viet-Hoang Nguyen Le, Linh Dieu Nguyen, Phuong Hoang Tran and Hai Truong Nguyen","doi":"10.1039/D4RE00169A","DOIUrl":null,"url":null,"abstract":"<p >In the past few years, there has been a prominent surge in the exploration of the synthesis of imidazole derivatives in synthetic organic chemistry. This growing interest arises from the wide range of potential applications offered by these compounds across various fields, encompassing industrial chemistry, pharmaceuticals, and medicinal chemistry. This study demonstrates an innovative synthesis of four-component eutectogels (ETGs), in particular ETG-Zr<small><sup>4+</sup></small>, for the production of imidazole derivatives. The ETG-Zr<small><sup>4+</sup></small> catalyst was characterized using FT-IR spectroscopy, SEM, TGA, and XRD, demonstrating its potential as a sustainable catalyst for the synthesis of poly-functionalized imidazole derivatives. The application of ETG-Zr<small><sup>4+</sup></small> as a catalyst afforded 1,2,4,5-tetraphenyl-1<em>H</em>-imidazole derivatives in 70–92% yields and 2,4,5-trisubstituted imidazole derivatives in 61–76% yields. Notably, the catalyst exhibits the advantage of reusability and promotes eco-friendly approaches <em>via</em> a one-pot, multi-component reaction pathway.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design and preparation of four-component eutectogels as a green and efficient catalyst for the one-pot multi-component synthesis of 1,2,4,5-tetrasubstituted and 2,4,5-trisubstituted imidazole derivatives under solvent-free conditions†\",\"authors\":\"Phat Ngoc Nguyen, Trung-Nhan Dong Tran, Nhat Minh Nguyen, Viet-Hoang Nguyen Le, Linh Dieu Nguyen, Phuong Hoang Tran and Hai Truong Nguyen\",\"doi\":\"10.1039/D4RE00169A\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >In the past few years, there has been a prominent surge in the exploration of the synthesis of imidazole derivatives in synthetic organic chemistry. This growing interest arises from the wide range of potential applications offered by these compounds across various fields, encompassing industrial chemistry, pharmaceuticals, and medicinal chemistry. This study demonstrates an innovative synthesis of four-component eutectogels (ETGs), in particular ETG-Zr<small><sup>4+</sup></small>, for the production of imidazole derivatives. The ETG-Zr<small><sup>4+</sup></small> catalyst was characterized using FT-IR spectroscopy, SEM, TGA, and XRD, demonstrating its potential as a sustainable catalyst for the synthesis of poly-functionalized imidazole derivatives. The application of ETG-Zr<small><sup>4+</sup></small> as a catalyst afforded 1,2,4,5-tetraphenyl-1<em>H</em>-imidazole derivatives in 70–92% yields and 2,4,5-trisubstituted imidazole derivatives in 61–76% yields. Notably, the catalyst exhibits the advantage of reusability and promotes eco-friendly approaches <em>via</em> a one-pot, multi-component reaction pathway.</p>\",\"PeriodicalId\":101,\"journal\":{\"name\":\"Reaction Chemistry & Engineering\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-06-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reaction Chemistry & Engineering\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2024/re/d4re00169a\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reaction Chemistry & Engineering","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/re/d4re00169a","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Design and preparation of four-component eutectogels as a green and efficient catalyst for the one-pot multi-component synthesis of 1,2,4,5-tetrasubstituted and 2,4,5-trisubstituted imidazole derivatives under solvent-free conditions†
In the past few years, there has been a prominent surge in the exploration of the synthesis of imidazole derivatives in synthetic organic chemistry. This growing interest arises from the wide range of potential applications offered by these compounds across various fields, encompassing industrial chemistry, pharmaceuticals, and medicinal chemistry. This study demonstrates an innovative synthesis of four-component eutectogels (ETGs), in particular ETG-Zr4+, for the production of imidazole derivatives. The ETG-Zr4+ catalyst was characterized using FT-IR spectroscopy, SEM, TGA, and XRD, demonstrating its potential as a sustainable catalyst for the synthesis of poly-functionalized imidazole derivatives. The application of ETG-Zr4+ as a catalyst afforded 1,2,4,5-tetraphenyl-1H-imidazole derivatives in 70–92% yields and 2,4,5-trisubstituted imidazole derivatives in 61–76% yields. Notably, the catalyst exhibits the advantage of reusability and promotes eco-friendly approaches via a one-pot, multi-component reaction pathway.
期刊介绍:
Reaction Chemistry & Engineering is a new journal reporting cutting edge research into all aspects of making molecules for the benefit of fundamental research, applied processes and wider society.
From fundamental, molecular-level chemistry to large scale chemical production, Reaction Chemistry & Engineering brings together communities of chemists and chemical engineers working to ensure the crucial role of reaction chemistry in today’s world.