A. V. Karpushev, V. B. Mikhailova, A. A. Kostareva, B. S. Zhorov
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引用次数: 0
摘要
摘要 热带驯养鱼 Danio rerio 越来越多地被用作人类心脏生理学和病理学电生理学研究的模型对象。丹瑞鱼的特点是在心率、动作电位形态等心脏电活动的功能参数以及细胞膜去极化和复极化的一组离子电流方面与人类相似。D. rerio 很容易培育，易于实验处理，也易于基因改造。本综述介绍了目前有关 D. rerio 心肌细胞中离子通道的结构和功能组织的数据。
Tropical teleost fish Danio rerio is increasingly used as a model object for electrophysiological studies of human cardiac physiology and pathology. D. rerio is characterized by the similarity with humans in such functional parameters of the electrical activity of the heart as heart rate, action potential morphology, as well as in a set of ion currents depolarizing and repolarizing the cell membrane. D. rerio is easy to breed, easy to handle experimentally, and easy to genetically modify. This overview presents current data on the structural and functional organization of ion channels in D. rerio heart myocytes.
期刊介绍：
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.
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