Amit Kumar Shakya, Ayushman Ramola, Surinder Singh, Anurag Vidyarthi
{"title":"癌症检测用等离子体生物传感器的优化设计:核心配置和诺贝尔材料涂层创新","authors":"Amit Kumar Shakya, Ayushman Ramola, Surinder Singh, Anurag Vidyarthi","doi":"10.1007/s11468-024-02400-7","DOIUrl":null,"url":null,"abstract":"<p>In this research, a new model of the photonic crystal fiber (PCF) biosensor, which uses the surface plasmon resonance (SPR) principle, is presented, with a focus on effectively identifying various cancerous cells in the human body. We specifically targeted six different types of cells, namely, Basal, Hela, Jurkat, PC 12, MDA MB 231, and MCF 7, which are linked to skin, cervical, blood, adrenal gland, and two types of breast cancers. The biosensor works by detecting shifts in resonance wavelength (RW) between healthy and infected cells. Our exploration involved a dual-mode investigation, considering both transverse magnetic (TM) and transverse electric (TE) polarization. The wavelength sensitivities (<span>\\({{\\varvec{S}}}_{{\\varvec{W}}}\\)</span>) of 4000, 3333.33, 6071.42, 6428.57, 8428.57, and 13,571.42 nm/RIU and 3520, 2916.66, 5000, 7142.85, 8571.42, and 12,857.14 nm/RIU, and amplitude sensitivities (<span>\\({{\\varvec{S}}}_{{\\varvec{A}}}\\)</span>) of 2482, 6124, 9773, 13,452, 15,289, and 18,651 RIU<sup>−1</sup> and 1467, 2683, 5845, 7243, 10,089, and 16,864 RIU<sup>−1</sup>, are obtained for TM and TE polarizations, respectively. A sensor resolution (<span>\\({{\\varvec{S}}}_{{\\varvec{R}}}\\)</span>) of the order 10<sup>−6</sup> is achieved for both polarizations. Owing to its high sensing parameters and a novel combination of materials, the proposed dual-mode PCF SPR sensor shows significant promise as a valuable tool for perceiving cancer cells, potentially aiding in the early detection and management of various forms of cancer.</p>","PeriodicalId":736,"journal":{"name":"Plasmonics","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Optimized Design of Plasmonic Biosensor for Cancer Detection: Core Configuration and Nobel Material Coating Innovation\",\"authors\":\"Amit Kumar Shakya, Ayushman Ramola, Surinder Singh, Anurag Vidyarthi\",\"doi\":\"10.1007/s11468-024-02400-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In this research, a new model of the photonic crystal fiber (PCF) biosensor, which uses the surface plasmon resonance (SPR) principle, is presented, with a focus on effectively identifying various cancerous cells in the human body. We specifically targeted six different types of cells, namely, Basal, Hela, Jurkat, PC 12, MDA MB 231, and MCF 7, which are linked to skin, cervical, blood, adrenal gland, and two types of breast cancers. The biosensor works by detecting shifts in resonance wavelength (RW) between healthy and infected cells. Our exploration involved a dual-mode investigation, considering both transverse magnetic (TM) and transverse electric (TE) polarization. The wavelength sensitivities (<span>\\\\({{\\\\varvec{S}}}_{{\\\\varvec{W}}}\\\\)</span>) of 4000, 3333.33, 6071.42, 6428.57, 8428.57, and 13,571.42 nm/RIU and 3520, 2916.66, 5000, 7142.85, 8571.42, and 12,857.14 nm/RIU, and amplitude sensitivities (<span>\\\\({{\\\\varvec{S}}}_{{\\\\varvec{A}}}\\\\)</span>) of 2482, 6124, 9773, 13,452, 15,289, and 18,651 RIU<sup>−1</sup> and 1467, 2683, 5845, 7243, 10,089, and 16,864 RIU<sup>−1</sup>, are obtained for TM and TE polarizations, respectively. A sensor resolution (<span>\\\\({{\\\\varvec{S}}}_{{\\\\varvec{R}}}\\\\)</span>) of the order 10<sup>−6</sup> is achieved for both polarizations. Owing to its high sensing parameters and a novel combination of materials, the proposed dual-mode PCF SPR sensor shows significant promise as a valuable tool for perceiving cancer cells, potentially aiding in the early detection and management of various forms of cancer.</p>\",\"PeriodicalId\":736,\"journal\":{\"name\":\"Plasmonics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-06-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasmonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1007/s11468-024-02400-7\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasmonics","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1007/s11468-024-02400-7","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Optimized Design of Plasmonic Biosensor for Cancer Detection: Core Configuration and Nobel Material Coating Innovation
In this research, a new model of the photonic crystal fiber (PCF) biosensor, which uses the surface plasmon resonance (SPR) principle, is presented, with a focus on effectively identifying various cancerous cells in the human body. We specifically targeted six different types of cells, namely, Basal, Hela, Jurkat, PC 12, MDA MB 231, and MCF 7, which are linked to skin, cervical, blood, adrenal gland, and two types of breast cancers. The biosensor works by detecting shifts in resonance wavelength (RW) between healthy and infected cells. Our exploration involved a dual-mode investigation, considering both transverse magnetic (TM) and transverse electric (TE) polarization. The wavelength sensitivities (\({{\varvec{S}}}_{{\varvec{W}}}\)) of 4000, 3333.33, 6071.42, 6428.57, 8428.57, and 13,571.42 nm/RIU and 3520, 2916.66, 5000, 7142.85, 8571.42, and 12,857.14 nm/RIU, and amplitude sensitivities (\({{\varvec{S}}}_{{\varvec{A}}}\)) of 2482, 6124, 9773, 13,452, 15,289, and 18,651 RIU−1 and 1467, 2683, 5845, 7243, 10,089, and 16,864 RIU−1, are obtained for TM and TE polarizations, respectively. A sensor resolution (\({{\varvec{S}}}_{{\varvec{R}}}\)) of the order 10−6 is achieved for both polarizations. Owing to its high sensing parameters and a novel combination of materials, the proposed dual-mode PCF SPR sensor shows significant promise as a valuable tool for perceiving cancer cells, potentially aiding in the early detection and management of various forms of cancer.
期刊介绍:
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.