Sahar Abdalla, Hela Ferjani, Ahmad M. Alsaad, Carlos J. Tavares, Ahmad D. Telfah
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Modeling a Graphene-Enhanced Surface Plasmon Resonance Sensor for Cancer Detection
This study presents an innovative surface plasmon resonance (SPR) biosensor model constructed with a glass prism coated first with a layer of silver followed by a graphene layer (glass prism/Ag/graphene). The biosensor was analyzed using a finite element method-based simulation platform. Evaluation of the SPR sensor was conducted using a range of normal and cancer cell lines, including Basal (skin cancer), HeLa (cervical cancer), Jurkat (blood cancer), PC12 (adrenal gland cancer), and MCF-7 (breast cancer) cells. The results demonstrate the biosensor’s effectiveness in detecting various cancerous cells across a wide range of refractive index variations. Sensitivity values for skin, cervical, blood, adrenal gland, and breast cancer cells are reported as 120.0 °/RIU, 200.0 °/RIU, 142.9 °/RIU, 114.3 °/RIU, and 114.3 °/RIU, respectively. This proposed biosensor model offers significant potential for a variety of bio-sensing applications.
期刊介绍:
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.