Elke Eriksen, Pål Graff, Anne Straumfors, Anani Afanou, Anne Mette Madsen, Alexander Eiler
{"title":"76 挪威废物分拣中的生物气溶胶接触","authors":"Elke Eriksen, Pål Graff, Anne Straumfors, Anani Afanou, Anne Mette Madsen, Alexander Eiler","doi":"10.1093/annweh/wxae035.032","DOIUrl":null,"url":null,"abstract":"Occupational exposure during handling and sorting of waste has previously been identified as causative agent for occupational disease. New work operations and technological progress facilitate the waste sorting industry with means to reach global sustainability goals, however, generate unknown work-exposure scenarios. Full-shift personal work air samples were collected to investigate levels of infectious and non-infectious microbial components in bioaerosols and to study the potential of organic dust to elicit an immune response in vitro (TLR activation cell model) and in vivo (plasma biomarkers). Large variation in assessed exposure measurements between and within WSP, as well as between seasons was identified. Dust levels were generally below the current Norwegian OEL (5mg/m3), however contained substantial levels of endotoxins, fungal particles, and microbial agents with immunostimulatory potential. Viable microorganisms in the inhalable fraction were dominated by fungi in the genus Aspergillus and bacteria in the genus Bacillus and Staphylococcus. The samples contained a substantial fraction of risk group 2 human pathogens. Thirty per cent of the organic dust samples elicited TLR activation in vitro. Monocyte levels, plasma levels of IL-1RA, IL-18 and TNFα as well as symptom prevalence of respiratory and general symptoms were higher among exposed waste workers compared to an unexposed control group. The present study indicates that Norwegian waste workers are potentially exposed to relatively high levels of microbial agents that may cause adverse health effects in susceptible individuals.","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"76 Bioaerosol exposure in Norwegian waste sorting\",\"authors\":\"Elke Eriksen, Pål Graff, Anne Straumfors, Anani Afanou, Anne Mette Madsen, Alexander Eiler\",\"doi\":\"10.1093/annweh/wxae035.032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Occupational exposure during handling and sorting of waste has previously been identified as causative agent for occupational disease. New work operations and technological progress facilitate the waste sorting industry with means to reach global sustainability goals, however, generate unknown work-exposure scenarios. Full-shift personal work air samples were collected to investigate levels of infectious and non-infectious microbial components in bioaerosols and to study the potential of organic dust to elicit an immune response in vitro (TLR activation cell model) and in vivo (plasma biomarkers). Large variation in assessed exposure measurements between and within WSP, as well as between seasons was identified. Dust levels were generally below the current Norwegian OEL (5mg/m3), however contained substantial levels of endotoxins, fungal particles, and microbial agents with immunostimulatory potential. Viable microorganisms in the inhalable fraction were dominated by fungi in the genus Aspergillus and bacteria in the genus Bacillus and Staphylococcus. The samples contained a substantial fraction of risk group 2 human pathogens. Thirty per cent of the organic dust samples elicited TLR activation in vitro. Monocyte levels, plasma levels of IL-1RA, IL-18 and TNFα as well as symptom prevalence of respiratory and general symptoms were higher among exposed waste workers compared to an unexposed control group. The present study indicates that Norwegian waste workers are potentially exposed to relatively high levels of microbial agents that may cause adverse health effects in susceptible individuals.\",\"PeriodicalId\":8362,\"journal\":{\"name\":\"Annals Of Work Exposures and Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals Of Work Exposures and Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/annweh/wxae035.032\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals Of Work Exposures and Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/annweh/wxae035.032","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Occupational exposure during handling and sorting of waste has previously been identified as causative agent for occupational disease. New work operations and technological progress facilitate the waste sorting industry with means to reach global sustainability goals, however, generate unknown work-exposure scenarios. Full-shift personal work air samples were collected to investigate levels of infectious and non-infectious microbial components in bioaerosols and to study the potential of organic dust to elicit an immune response in vitro (TLR activation cell model) and in vivo (plasma biomarkers). Large variation in assessed exposure measurements between and within WSP, as well as between seasons was identified. Dust levels were generally below the current Norwegian OEL (5mg/m3), however contained substantial levels of endotoxins, fungal particles, and microbial agents with immunostimulatory potential. Viable microorganisms in the inhalable fraction were dominated by fungi in the genus Aspergillus and bacteria in the genus Bacillus and Staphylococcus. The samples contained a substantial fraction of risk group 2 human pathogens. Thirty per cent of the organic dust samples elicited TLR activation in vitro. Monocyte levels, plasma levels of IL-1RA, IL-18 and TNFα as well as symptom prevalence of respiratory and general symptoms were higher among exposed waste workers compared to an unexposed control group. The present study indicates that Norwegian waste workers are potentially exposed to relatively high levels of microbial agents that may cause adverse health effects in susceptible individuals.
期刊介绍:
About the Journal
Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?"
We are interested in high quality scientific research addressing:
the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures;
the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities;
populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers;
the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems;
policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities;
methodologies and mechanisms that underlie the quantification and/or control of exposure and risk.
There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.