Anne Farbrot, Tobias Storsjö, Cecilia Nilsson, Håkan Tinnerberg
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Recently we therefore presented a method that is cost-effective and easy-to-use based on quantification of elemental carbon (EC). Aim To find out which toxicological methods that can be relevant for the study of local or systemic effects from graphene exposure through the respiratory system and bring the knowledge to discussion. Method Literature review focusing on methods that are or might be relevant to graphene deposition and uptake in the lower respiratory system. Outcome A mapping of methods and their respective end points that can be related to adverse outcomes in humans. The mapping reveals that there is still a knowledge gap going from toxicity testing to human risk assessment. Conclusions There is a need to discuss and decide on further and complementary testing. The present study brings two different starting points.","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"221 Risk assessment of occupational exposure to graphene nanoforms - Where are we?\",\"authors\":\"Anne Farbrot, Tobias Storsjö, Cecilia Nilsson, Håkan Tinnerberg\",\"doi\":\"10.1093/annweh/wxae035.084\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background Graphene is a 2D-material with many useful properties such as flexibility, elasticity, and conductivity among others. Graphene could therefore become a material used in many occupational fields in the future, and thereby lead to occupational exposure. Today, neither intrinsic hazards with the material in occupational settings nor the extent of exposures are sufficiently known in order to form a basis for occupational risk assessment. There are many publications (>300) dealing with toxicity of graphene and graphene forms, but an evident, reliable and broadly agreed link to human exposure is lacking. In parallel, occupational exposure assessment targeting graphene has suffered from the lack of efficient measuring techniques. Recently we therefore presented a method that is cost-effective and easy-to-use based on quantification of elemental carbon (EC). Aim To find out which toxicological methods that can be relevant for the study of local or systemic effects from graphene exposure through the respiratory system and bring the knowledge to discussion. Method Literature review focusing on methods that are or might be relevant to graphene deposition and uptake in the lower respiratory system. Outcome A mapping of methods and their respective end points that can be related to adverse outcomes in humans. The mapping reveals that there is still a knowledge gap going from toxicity testing to human risk assessment. Conclusions There is a need to discuss and decide on further and complementary testing. 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221 Risk assessment of occupational exposure to graphene nanoforms - Where are we?
Background Graphene is a 2D-material with many useful properties such as flexibility, elasticity, and conductivity among others. Graphene could therefore become a material used in many occupational fields in the future, and thereby lead to occupational exposure. Today, neither intrinsic hazards with the material in occupational settings nor the extent of exposures are sufficiently known in order to form a basis for occupational risk assessment. There are many publications (>300) dealing with toxicity of graphene and graphene forms, but an evident, reliable and broadly agreed link to human exposure is lacking. In parallel, occupational exposure assessment targeting graphene has suffered from the lack of efficient measuring techniques. Recently we therefore presented a method that is cost-effective and easy-to-use based on quantification of elemental carbon (EC). Aim To find out which toxicological methods that can be relevant for the study of local or systemic effects from graphene exposure through the respiratory system and bring the knowledge to discussion. Method Literature review focusing on methods that are or might be relevant to graphene deposition and uptake in the lower respiratory system. Outcome A mapping of methods and their respective end points that can be related to adverse outcomes in humans. The mapping reveals that there is still a knowledge gap going from toxicity testing to human risk assessment. Conclusions There is a need to discuss and decide on further and complementary testing. The present study brings two different starting points.
期刊介绍:
About the Journal
Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?"
We are interested in high quality scientific research addressing:
the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures;
the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities;
populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers;
the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems;
policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities;
methodologies and mechanisms that underlie the quantification and/or control of exposure and risk.
There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.