Event Triggered Constrained Regulatory Control of Blood Glucose in Type I Diabetes Mellitus Condition

Application of process control techniques to biomedical problems has always been fascinating the medical community. Effective control strategies for automation of insulin infusion are seeking attention among researchers in lieu of the manual insulin infusion. This paper investigates the possibilities of designing an event triggered mechanism based constrained selective next generation RTD-A controller. The advantageous features of this technique are simplicity, flexibility in tuning, closed form solution similar to the PID controller and superior in performance like predictive controllers. Avoiding redundant data being transmitted to the controller and hence bandwidth utilization for the data transmission could be avoided by the incorporation of such event triggered mechanism. The performance of the developed controller is validated in the presence of constraints imposed on the insulin infusion input rate and amplitude to avoid hyperglycemia. The comparative simulation results of DMC, IMC and next generation RTD-A controllers in constrained and unconstrained environment are presented. Performance evaluation of the constrained blood glucose regulation with and without event triggered mechanism is also verified in simulation. The supreme quality of the event based constrained selective next generation RTD-A controller is its effective reduction in the redundancy in data transmission, effective bandwidth utilization and independent tuning capability.