Jiawei Zhang, Tiantian Guo, Kunlun Liu, Ke Bao, Xinyi Liu, Sifan Cui, Dixuan Chen, Mulin Jun Li, Siqi Bao, Chunhong Hu, Xi Wei, Xiujun Gao
{"title":"利用多功能中空介孔硅纳米粒子对肿瘤进行超声波诊断和治疗","authors":"Jiawei Zhang, Tiantian Guo, Kunlun Liu, Ke Bao, Xinyi Liu, Sifan Cui, Dixuan Chen, Mulin Jun Li, Siqi Bao, Chunhong Hu, Xi Wei, Xiujun Gao","doi":"10.1021/acsanm.4c02319","DOIUrl":null,"url":null,"abstract":"In recent years, the application of hollow mesoporous silicon nanoparticles in the biomedical field has attracted much attention because of their excellent features. In this study, the sonosensitizer curcumin (Cur), the chemotherapy drug doxorubicin (Dox), and the perfluoropropane (C<sub>3</sub>F<sub>8</sub>) gas were loaded into a multifunctional hollow mesoporous silica nanoparticle (MHMSN). The surface of MHMSN was modified with a biotin molecule and acid-sensitive groups (cis-aconitic anhydride-polyethylene glycol, CDM-PEG). The as-prepared multifunctional nanoparticle (CDF-MHMSN) demonstrates improved therapeutic efficacy and enhanced tumor contrast ultrasound performance. Surface-modified CDM-PEG can improve the blood circulation ability of nanoparticles and peel off in the acidic tumor microenvironment, which can enhance the endocytosis of cancer cells. As a sonosensitizer, Cur could generate reactive oxygen species (ROS) under ultrasound stimulation to kill tumor cells and reduce the multidrug resistance of tumor cells to the Dox by inhibiting the expression of P-glycoprotein. Overall, CDF-MHMSN exhibits good biocompatibility, excellent ultrasound imaging capability, and effective antitumor ability, which may contribute to improving the treatment strategy for hepatocellular carcinoma.","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ultrasonic Diagnosis and Treatment of Tumors Using Multifunctional Hollow Mesoporous Silicon Nanoparticles\",\"authors\":\"Jiawei Zhang, Tiantian Guo, Kunlun Liu, Ke Bao, Xinyi Liu, Sifan Cui, Dixuan Chen, Mulin Jun Li, Siqi Bao, Chunhong Hu, Xi Wei, Xiujun Gao\",\"doi\":\"10.1021/acsanm.4c02319\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In recent years, the application of hollow mesoporous silicon nanoparticles in the biomedical field has attracted much attention because of their excellent features. In this study, the sonosensitizer curcumin (Cur), the chemotherapy drug doxorubicin (Dox), and the perfluoropropane (C<sub>3</sub>F<sub>8</sub>) gas were loaded into a multifunctional hollow mesoporous silica nanoparticle (MHMSN). The surface of MHMSN was modified with a biotin molecule and acid-sensitive groups (cis-aconitic anhydride-polyethylene glycol, CDM-PEG). The as-prepared multifunctional nanoparticle (CDF-MHMSN) demonstrates improved therapeutic efficacy and enhanced tumor contrast ultrasound performance. Surface-modified CDM-PEG can improve the blood circulation ability of nanoparticles and peel off in the acidic tumor microenvironment, which can enhance the endocytosis of cancer cells. As a sonosensitizer, Cur could generate reactive oxygen species (ROS) under ultrasound stimulation to kill tumor cells and reduce the multidrug resistance of tumor cells to the Dox by inhibiting the expression of P-glycoprotein. Overall, CDF-MHMSN exhibits good biocompatibility, excellent ultrasound imaging capability, and effective antitumor ability, which may contribute to improving the treatment strategy for hepatocellular carcinoma.\",\"PeriodicalId\":6,\"journal\":{\"name\":\"ACS Applied Nano Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Nano Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1021/acsanm.4c02319\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Nano Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1021/acsanm.4c02319","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
近年来,中空介孔硅纳米颗粒因其优异的特性在生物医学领域的应用备受关注。本研究将声敏剂姜黄素(Cur)、化疗药物多柔比星(Dox)和全氟丙烷(C3F8)气体载入多功能中空介孔硅纳米颗粒(MHMSN)。MHMSN 表面修饰了生物素分子和酸敏感基团(顺式乌头酸酐-聚乙二醇,CDM-PEG)。制备的多功能纳米粒子(CDF-MHMSN)具有更好的疗效和更强的肿瘤对比超声性能。表面修饰的 CDM-PEG 可提高纳米粒子的血液循环能力,并在酸性肿瘤微环境中剥离,从而增强对癌细胞的内吞作用。作为一种声敏剂,Cur 能在超声刺激下产生活性氧(ROS),杀死肿瘤细胞,并通过抑制 P 糖蛋白的表达,降低肿瘤细胞对 Dox 的多药耐药性。总之,CDF-MHMSN具有良好的生物相容性、优异的超声成像能力和有效的抗肿瘤能力,有助于改善肝细胞癌的治疗策略。
Ultrasonic Diagnosis and Treatment of Tumors Using Multifunctional Hollow Mesoporous Silicon Nanoparticles
In recent years, the application of hollow mesoporous silicon nanoparticles in the biomedical field has attracted much attention because of their excellent features. In this study, the sonosensitizer curcumin (Cur), the chemotherapy drug doxorubicin (Dox), and the perfluoropropane (C3F8) gas were loaded into a multifunctional hollow mesoporous silica nanoparticle (MHMSN). The surface of MHMSN was modified with a biotin molecule and acid-sensitive groups (cis-aconitic anhydride-polyethylene glycol, CDM-PEG). The as-prepared multifunctional nanoparticle (CDF-MHMSN) demonstrates improved therapeutic efficacy and enhanced tumor contrast ultrasound performance. Surface-modified CDM-PEG can improve the blood circulation ability of nanoparticles and peel off in the acidic tumor microenvironment, which can enhance the endocytosis of cancer cells. As a sonosensitizer, Cur could generate reactive oxygen species (ROS) under ultrasound stimulation to kill tumor cells and reduce the multidrug resistance of tumor cells to the Dox by inhibiting the expression of P-glycoprotein. Overall, CDF-MHMSN exhibits good biocompatibility, excellent ultrasound imaging capability, and effective antitumor ability, which may contribute to improving the treatment strategy for hepatocellular carcinoma.
期刊介绍:
ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.