线性区室模型可识别性数据库

Natali Gogishvili
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引用次数: 0

摘要

在进行实验并从时间序列数据推断参数值时,我们想知道参数值是全局可识别、局部可识别还是不可识别。参数的全局可识别性表明推断问题只有一种可能的解决方案,局部可识别性表明可能有几种(但有限多)可能性,而不可识别性则意味着参数值有无限多的可能性。掌握这一信息非常有用,因为举例来说,人们只会对可识别的参数进行推断。鉴于目前在这一领域开展的重要而广泛的研究,我们决定建立一个线性区间模型及其可识别性结果的数据库。这有助于检验定理和猜想,并得出可识别性结论。通过只存储对称和同构的模型,我们优化了内存效率,减少了查询时间。最后,我们将数据库应用到实际问题中。我们测试了关于删除论文中线性隔室模型状态的一个泄漏的猜想:输入-输出方程和保留可识别性的操作 "一文中关于删除一个模型状态泄漏的猜想进行了测试,并成功生成了一个实例。我们还计算了一些与线性区间模型参数可识别性有关的有趣统计数据。
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Database for identifiability properties of linear compartmental models
Structural identifiability is an important property of parametric ODE models. When conducting an experiment and inferring the parameter value from the time-series data, we want to know if the value is globally, locally, or non-identifiable. Global identifiability of the parameter indicates that there exists only one possible solution to the inference problem, local identifiability suggests that there could be several (but finitely many) possibilities, while non-identifiability implies that there are infinitely many possibilities for the value. Having this information is useful since, one would, for example, only perform inferences for the parameters which are identifiable. Given the current significance and widespread research conducted in this area, we decided to create a database of linear compartment models and their identifiability results. This facilitates the process of checking theorems and conjectures and drawing conclusions on identifiability. By only storing models up to symmetries and isomorphisms, we optimize memory efficiency and reduce query time. We conclude by applying our database to real problems. We tested a conjecture about deleting one leak of the model states in the paper 'Linear compartmental models: Input-output equations and operations that preserve identifiability' by E. Gross et al., and managed to produce a counterexample. We also compute some interesting statistics related to the identifiability of linear compartment model parameters.
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