Electrochemically enabled cobalt catalyzed enantioselective C–H acyloxylation of aryl phosphamide with carboxylic acid†

We presented a first example of cobalt-electro-catalyzed enantioselective C–H acyloxylation of arylphosphinamides with carboxylic acids, enabling the concise synthesis of oxygenated phosphamides featuring a P-stereogenic center. These compounds were synthesized with acceptable yields and outstanding enantioselectivities. The reaction demonstrated a broad substrate scope and good functional group tolerance. Additionally, the facile conversion of the acyloxy group to a free hydroxyl group provides opportunities for further chemical manipulations, underscoring the versatility of this strategy.