{"title":"有机合成中的可见光诱导溴自由基增强氢原子转移 (HAT) 反应","authors":"Barakha Saxena, Roshan I. Patel and Anuj Sharma","doi":"10.1039/D4SU00214H","DOIUrl":null,"url":null,"abstract":"<p >Hydrogen atom transfer (HAT) reactions have gained prominence in organic synthesis for providing a straightforward approach towards C–H bond activation for the formation of C-centered radical intermediates. However, halogen radical-assisted hydrogen atom transfer (HAT) reactions have become an interesting tool for C–H bond activation, facilitating the formation of C–C and C–X bonds. In particular, the bromine radical (Br˙) has garnered attention because of its remarkable capability as a hydrogen acceptor, which abstracts an H-atom from a C–H bond and generates a C-centered radical intermediate. Typically, transition metal- and organo-photocatalysts are commonly used to generate a bromine radical (Br˙) from a bromine anion (Br<small><sup>−</sup></small>). This newly generated bromine radical (Br˙) is useful in several organic transformations <em>via</em> C–H bond activation. In this review, we provide recent updates on bromine radical (Br˙) assisted hydrogen atom transfer (HAT) reactions with their scope, mechanism, and limitations.</p>","PeriodicalId":74745,"journal":{"name":"RSC sustainability","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/su/d4su00214h?page=search","citationCount":"0","resultStr":"{\"title\":\"Visible light-induced bromine radical enhanced hydrogen atom transfer (HAT) reactions in organic synthesis\",\"authors\":\"Barakha Saxena, Roshan I. Patel and Anuj Sharma\",\"doi\":\"10.1039/D4SU00214H\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Hydrogen atom transfer (HAT) reactions have gained prominence in organic synthesis for providing a straightforward approach towards C–H bond activation for the formation of C-centered radical intermediates. However, halogen radical-assisted hydrogen atom transfer (HAT) reactions have become an interesting tool for C–H bond activation, facilitating the formation of C–C and C–X bonds. In particular, the bromine radical (Br˙) has garnered attention because of its remarkable capability as a hydrogen acceptor, which abstracts an H-atom from a C–H bond and generates a C-centered radical intermediate. Typically, transition metal- and organo-photocatalysts are commonly used to generate a bromine radical (Br˙) from a bromine anion (Br<small><sup>−</sup></small>). This newly generated bromine radical (Br˙) is useful in several organic transformations <em>via</em> C–H bond activation. In this review, we provide recent updates on bromine radical (Br˙) assisted hydrogen atom transfer (HAT) reactions with their scope, mechanism, and limitations.</p>\",\"PeriodicalId\":74745,\"journal\":{\"name\":\"RSC sustainability\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.rsc.org/en/content/articlepdf/2024/su/d4su00214h?page=search\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"RSC sustainability\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2024/su/d4su00214h\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"RSC sustainability","FirstCategoryId":"1085","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/su/d4su00214h","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Visible light-induced bromine radical enhanced hydrogen atom transfer (HAT) reactions in organic synthesis
Hydrogen atom transfer (HAT) reactions have gained prominence in organic synthesis for providing a straightforward approach towards C–H bond activation for the formation of C-centered radical intermediates. However, halogen radical-assisted hydrogen atom transfer (HAT) reactions have become an interesting tool for C–H bond activation, facilitating the formation of C–C and C–X bonds. In particular, the bromine radical (Br˙) has garnered attention because of its remarkable capability as a hydrogen acceptor, which abstracts an H-atom from a C–H bond and generates a C-centered radical intermediate. Typically, transition metal- and organo-photocatalysts are commonly used to generate a bromine radical (Br˙) from a bromine anion (Br−). This newly generated bromine radical (Br˙) is useful in several organic transformations via C–H bond activation. In this review, we provide recent updates on bromine radical (Br˙) assisted hydrogen atom transfer (HAT) reactions with their scope, mechanism, and limitations.