脓疱型银屑病的治疗；未来之路

IF 1 4区医学 Q4 DERMATOLOGY Indian Journal of Dermatology Pub Date : 2024-06-26 DOI:10.4103/ijd.ijd_165_24

Shrichand G. Parasramani, Bikash R. Kar, Sushil Tahiliani, Anchala Parthasarathi, Shekhar Neema, Satyaki Ganguly, Dharshini Sathishkumar, K Venkatachalam, Haritha Komeravelli, Jayakar Thomas

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引用次数: 0

摘要

脓疱型银屑病是银屑病的一种特殊变异型，如果不尽早治疗，可能会危及生命。其发病机制最近与白细胞介素 36 的作用有关。除皮质类固醇激素外，阿昔曲汀、环孢素和甲氨蝶呤等全身性抗肿瘤药物也已被使用，但效果并不理想。最近，IL-36 在脓疱型银屑病发病机制中的作用被确认，针对 IL-36 受体的生物制剂已被用于治疗脓疱型银屑病，并取得了很大成功。本综述将介绍脓疱型银屑病发病机制的最新概念以及目前的治疗方案。

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Management of Pustular Psoriasis; The Way Ahead

Pustular psoriasis is a specialized variant of psoriasis which can be life threatening if not treated at the earliest. The pathogenesis has been recently linked to the role of interleukin 36. Apart from the corticosteroids, systemic antipsoriatics like acitretin, cyclosporine and methotrexate have been used with some success though unpredictable. With recent identification of role of IL-36 in the pathogenesis of pustular psoriasis, biologics targeting the IL-36 receptors have been used to manage the situation with high degree of success. This narrative review deals with the recent concepts of pathogenesis of pustular psoriasis as well as the current management scenario.

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来源期刊

Indian Journal of Dermatology Medicine-Dermatology

CiteScore

1.80

自引率

0.00%

发文量

217

审稿时长

47 weeks

期刊介绍： The journal publishes information related to skin-pathology and different modes of therapeutics, including dermatosurgery and cosmetic dermatology. Likewise, it carries articles on leprosy, STI and HIV/AIDS. The editorial board encourages the authors to publish articles addressing emerging techniques and developments in the subject specialty, in the form of Original investigations, Narrative and Systematic Reviews as well as Case Reports. The journal aims at publishing Editorials and Commentaries from eminent personalities on a regular basis.