探索心外膜细胞表面之外的功能

IF 16.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Circulation research Pub Date : 2024-07-05 Epub Date: 2024-07-04 DOI:10.1161/CIRCRESAHA.124.321567
David Wong, Julie Martinez, Pearl Quijada
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引用次数: 0

摘要

心外膜以前被视为心脏周围的一个被动外层,现在被认为是心脏发育、再生和修复的重要组成部分。在这篇综述中,我们将探讨心外膜的细胞和分子构成,重点介绍心外膜在斑马鱼和蝾螈的心脏再生和修复中的作用,以及心外膜在哺乳动物幼年和成年后的激活过程。我们还考察了用于研究心外膜细胞功能以进行治疗干预的最新技术。对高度再生动物模型的分析表明,心外膜在调节心肌细胞增殖、短暂纤维化和新生血管方面至关重要。然而,尽管心外膜具有解决心脏损伤的独特细胞程序,但目前仍不清楚如何在非再生哺乳动物体内复制这些过程。心肌梗死期间,心外膜细胞分泌信号因子,调节纤维化、血管和炎症重塑,从而不同程度地增强或抑制心脏修复。最近的转录组学研究验证了心外膜在不同物种和发育阶段的细胞和分子异质性,进一步揭示了心外膜在病理条件下的功能。这些研究还深入揭示了源自心外膜的调控信号分子在各种疾病中的功能,这可能会带来新的疗法和心血管修复医学的进步。此外,研究心外膜细胞功能所获得的洞察力也促进了新技术的发展,包括使用人类多能干细胞和心脏器官组织来模拟心血管系统内的修复过程。人们对心外膜功能的了解不断加深,有望开发出创新的治疗策略,以解决心脏发育障碍、增强再生疗法和缓解心血管疾病进展。
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Exploring the Function of Epicardial Cells Beyond the Surface.

The epicardium, previously viewed as a passive outer layer around the heart, is now recognized as an essential component in development, regeneration, and repair. In this review, we explore the cellular and molecular makeup of the epicardium, highlighting its roles in heart regeneration and repair in zebrafish and salamanders, as well as its activation in young and adult postnatal mammals. We also examine the latest technologies used to study the function of epicardial cells for therapeutic interventions. Analysis of highly regenerative animal models shows that the epicardium is essential in regulating cardiomyocyte proliferation, transient fibrosis, and neovascularization. However, despite the epicardium's unique cellular programs to resolve cardiac damage, it remains unclear how to replicate these processes in nonregenerative mammalian organisms. During myocardial infarction, epicardial cells secrete signaling factors that modulate fibrotic, vascular, and inflammatory remodeling, which differentially enhance or inhibit cardiac repair. Recent transcriptomic studies have validated the cellular and molecular heterogeneity of the epicardium across various species and developmental stages, shedding further light on its function under pathological conditions. These studies have also provided insights into the function of regulatory epicardial-derived signaling molecules in various diseases, which could lead to new therapies and advances in reparative cardiovascular medicine. Moreover, insights gained from investigating epicardial cell function have initiated the development of novel techniques, including using human pluripotent stem cells and cardiac organoids to model reparative processes within the cardiovascular system. This growing understanding of epicardial function holds the potential for developing innovative therapeutic strategies aimed at addressing developmental heart disorders, enhancing regenerative therapies, and mitigating cardiovascular disease progression.

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来源期刊
Circulation research
Circulation research 医学-外周血管病
CiteScore
29.60
自引率
2.00%
发文量
535
审稿时长
3-6 weeks
期刊介绍: Circulation Research is a peer-reviewed journal that serves as a forum for the highest quality research in basic cardiovascular biology. The journal publishes studies that utilize state-of-the-art approaches to investigate mechanisms of human disease, as well as translational and clinical research that provide fundamental insights into the basis of disease and the mechanism of therapies. Circulation Research has a broad audience that includes clinical and academic cardiologists, basic cardiovascular scientists, physiologists, cellular and molecular biologists, and cardiovascular pharmacologists. The journal aims to advance the understanding of cardiovascular biology and disease by disseminating cutting-edge research to these diverse communities. In terms of indexing, Circulation Research is included in several prominent scientific databases, including BIOSIS, CAB Abstracts, Chemical Abstracts, Current Contents, EMBASE, and MEDLINE. This ensures that the journal's articles are easily discoverable and accessible to researchers in the field. Overall, Circulation Research is a reputable publication that attracts high-quality research and provides a platform for the dissemination of important findings in basic cardiovascular biology and its translational and clinical applications.
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