Rui Zuo, Shuang Liu, Wenbo Li, Zhu Xia, Lu Xu, Hua Pang
{"title":"68Ga-pentixafor PET/CT 在原发性醛固酮增多症和双侧病变患者中的临床价值：一项单中心研究的初步结果。","authors":"Rui Zuo, Shuang Liu, Wenbo Li, Zhu Xia, Lu Xu, Hua Pang","doi":"10.1186/s13550-024-01125-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Subtype diagnosis of primary aldosteronism (PA) is used to determine treatment, and the potential utility of <sup>68</sup>Ga-pentixafor PET/CT for investigation of PA has long been recognized. The study aimed to evaluate the clinical value of <sup>68</sup>Ga-pentixafor PET/CT in the diagnosis and prognosis of patients with bilateral lesions identified by CT.</p><p><strong>Methods: </strong>In total, 25 patients with PA and bilateral lesions on CT were retrospectively evaluated. All patients underwent <sup>68</sup>Ga-Pentixafor PET/CT and adrenal vein sampling. The analysis focused on establishing the relationship between bilateral adrenal lesions SUVmax and the ratio of bilateral adrenal lesions SUVmax (CON) and clinical diagnosis, treatment outcomes, and KCNJ5 gene status.</p><p><strong>Results: </strong>The concordance rate between <sup>68</sup>Ga-Pentixafor PET/CT and adrenal venous sampling was 65.2% (15/23). The lateralization results of <sup>68</sup>Ga-pentixafor PET/CT supported the clinical decisions of 20 patients with PA, 90% of whom showed effectiveness in treatment. The SUVmax on the dominant side of the surgically treated patients was higher than that of patients treated with drugs. The SUVmax of the KCNJ5 mutant group was higher than that of the KCNJ5 wild group, and <sup>68</sup>Ga-Pentixafor uptake was correlated with KCNJ5 gene status.</p><p><strong>Conclusions: </strong><sup>68</sup>Ga-Pentixafor PET/CT proves beneficial for patients with PA with bilateral lesions on CT. The treatment is generally effective based on the results of PET lateralization. Simultaneously, a certain relationship exists between <sup>68</sup>Ga-Pentixafor PET/CT and KCNJ5 gene status, warranting further analysis.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224210/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical value of <sup>68</sup>Ga-pentixafor PET/CT in patients with primary aldosteronism and bilateral lesions: preliminary results of a single-centre study.\",\"authors\":\"Rui Zuo, Shuang Liu, Wenbo Li, Zhu Xia, Lu Xu, Hua Pang\",\"doi\":\"10.1186/s13550-024-01125-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Subtype diagnosis of primary aldosteronism (PA) is used to determine treatment, and the potential utility of <sup>68</sup>Ga-pentixafor PET/CT for investigation of PA has long been recognized. The study aimed to evaluate the clinical value of <sup>68</sup>Ga-pentixafor PET/CT in the diagnosis and prognosis of patients with bilateral lesions identified by CT.</p><p><strong>Methods: </strong>In total, 25 patients with PA and bilateral lesions on CT were retrospectively evaluated. All patients underwent <sup>68</sup>Ga-Pentixafor PET/CT and adrenal vein sampling. The analysis focused on establishing the relationship between bilateral adrenal lesions SUVmax and the ratio of bilateral adrenal lesions SUVmax (CON) and clinical diagnosis, treatment outcomes, and KCNJ5 gene status.</p><p><strong>Results: </strong>The concordance rate between <sup>68</sup>Ga-Pentixafor PET/CT and adrenal venous sampling was 65.2% (15/23). The lateralization results of <sup>68</sup>Ga-pentixafor PET/CT supported the clinical decisions of 20 patients with PA, 90% of whom showed effectiveness in treatment. The SUVmax on the dominant side of the surgically treated patients was higher than that of patients treated with drugs. The SUVmax of the KCNJ5 mutant group was higher than that of the KCNJ5 wild group, and <sup>68</sup>Ga-Pentixafor uptake was correlated with KCNJ5 gene status.</p><p><strong>Conclusions: </strong><sup>68</sup>Ga-Pentixafor PET/CT proves beneficial for patients with PA with bilateral lesions on CT. The treatment is generally effective based on the results of PET lateralization. Simultaneously, a certain relationship exists between <sup>68</sup>Ga-Pentixafor PET/CT and KCNJ5 gene status, warranting further analysis.</p>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224210/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s13550-024-01125-2\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13550-024-01125-2","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Clinical value of 68Ga-pentixafor PET/CT in patients with primary aldosteronism and bilateral lesions: preliminary results of a single-centre study.
Background: Subtype diagnosis of primary aldosteronism (PA) is used to determine treatment, and the potential utility of 68Ga-pentixafor PET/CT for investigation of PA has long been recognized. The study aimed to evaluate the clinical value of 68Ga-pentixafor PET/CT in the diagnosis and prognosis of patients with bilateral lesions identified by CT.
Methods: In total, 25 patients with PA and bilateral lesions on CT were retrospectively evaluated. All patients underwent 68Ga-Pentixafor PET/CT and adrenal vein sampling. The analysis focused on establishing the relationship between bilateral adrenal lesions SUVmax and the ratio of bilateral adrenal lesions SUVmax (CON) and clinical diagnosis, treatment outcomes, and KCNJ5 gene status.
Results: The concordance rate between 68Ga-Pentixafor PET/CT and adrenal venous sampling was 65.2% (15/23). The lateralization results of 68Ga-pentixafor PET/CT supported the clinical decisions of 20 patients with PA, 90% of whom showed effectiveness in treatment. The SUVmax on the dominant side of the surgically treated patients was higher than that of patients treated with drugs. The SUVmax of the KCNJ5 mutant group was higher than that of the KCNJ5 wild group, and 68Ga-Pentixafor uptake was correlated with KCNJ5 gene status.
Conclusions: 68Ga-Pentixafor PET/CT proves beneficial for patients with PA with bilateral lesions on CT. The treatment is generally effective based on the results of PET lateralization. Simultaneously, a certain relationship exists between 68Ga-Pentixafor PET/CT and KCNJ5 gene status, warranting further analysis.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
