超声引导下经皮射频消融治疗滑膜增生的有效性和安全性。

IF 3 3区 医学 Q2 ONCOLOGY International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-07-04 DOI:10.1080/02656736.2024.2328113
Qi Xu, Xiao-Hui Xu, Ze-Zheng Liu, Jian-Bi Zhu, Huan-Huan Ding, Chun-Chun Jin, Zhi-Han Yan
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引用次数: 0

摘要

目的:本研究旨在探讨超声引导下经皮射频消融术(RFA)治疗抗原诱发关节炎(AIA)模型兔膝关节滑膜增生的有效性和安全性:方法:将 40 只日本大耳白兔分为 AIA 组和对照组。成功诱导 AIA 模型后,将膝关节随机分配到 RFA 组和非 RFA 组。RFA组在超声引导下进行RFA治疗膝关节滑膜增生。对各种检测指标进行动态观察,以评估RFA手术的安全性和有效性:结果:RFA组成功实现了滑膜消融,术中和围术期无死亡病例。术后膝关节周径达到峰值,然后在术后第三周下降。术后皮肤溃疡的发生率和直径与非RFA组相比没有明显差异(P > .05)。解剖检查显示,RFA 组消融区域周围的肌间筋膜完好无损。消融的滑膜组织最初呈白色块状,随后液化成乳白色粘稠液体。病理组织学观察到关节软骨毛糙,滑膜液化坏死,周围软组织有炎性细胞浸润:实验结果表明,超声引导下膝关节 RFA 治疗 AIA 模型动物滑膜增生既有效又安全。
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Efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation for synovial hyperplasia.

Purpose: This study aimed to investigate the efficacy and safety of ultrasound-guided percutaneous radiofrequency ablation (RFA) for the treatment of synovial hyperplasia in the knee joints of antigen-induced arthritis (AIA) model rabbits.

Methods: Forty Japanese large-eared white rabbits were divided into AIA and control groups. After successful induction of the AIA model, the knee joints were randomly assigned to RFA and non-RFA groups. The RFA group underwent ultrasound-guided RFA to treat synovial hyperplasia in the knee joint. Dynamic observation of various detection indices was conducted to evaluate the safety and effectiveness of the RFA procedure.

Results: Successful synovial ablation was achieved in the RFA group, with no intraoperative or perioperative mortality. Postoperative the circumference of the knee joint reached a peak before decreasing in the third week after surgery. The incidence and diameter of postoperative skin ulcers were not significantly different compared to the non-RFA group (p > .05). Anatomical examination revealed an intact intermuscular fascia around the ablated area in the RFA group. The ablated synovial tissue initially presented as a white mass, which subsequently liquefied into a milky white viscous fluid. Gross articular cartilage was observed, along with liquefied necrosis of the synovium on pathological histology and infiltration of inflammatory cells in the surrounding soft tissue.

Conclusion: The experimental results demonstrated that ultrasound-guided RFA of the knee in the treatment of synovial hyperplasia in AIA model animals was both effective and safe.

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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
期刊最新文献
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