体内高频定量超声波得出的前巩膜参数与近视程度和葡萄肿的存在相关。

IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Clinical and Experimental Ophthalmology Pub Date : 2024-07-04 DOI:10.1111/ceo.14415
Cameron Hoerig PhD, Quan V. Hoang MD, PhD, Jonathan Mamou PhD
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引用次数: 0

摘要

背景:方法:使用高频护理点(POC)超声仪器,利用定量超声(QUS)方法计算的参数,评估体内前巩膜的微观结构和生物力学特性:在这项横断面研究中,使用 POC 仪器扫描了 85 名入选患者的双眼,并对超声波数据进行了处理,以获得 QUS 参数。采用皮尔逊相关和多线性回归来确定 QUS 参数与屈光不正(RE)或轴向长度之间的关系。根据 RE 对眼睛进行分类后,使用 QUS 或眼科参数(前房深度、角膜中央厚度、角膜力和眼压)训练二元支持向量机 (SVM) 分类器,对每只眼睛进行分类。通过计算接收者工作特征曲线下面积(AUC)来评估分类器的性能:结果:单个 QUS 参数与 RE 和轴长相关(p 结论:QUS 参数与眼压和眼压的进展相关:QUS 参数与近视度数的进展相关,并可指示近视引起的前巩膜微结构和生物力学变化。这些方法可提供重要的临床信息,补充标准眼科测量方法,用于预测近视进展和评估后葡萄膜瘤形成的风险。
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In-vivo high-frequency quantitative ultrasound-derived parameters of the anterior sclera correlated with level of myopia and presence of staphyloma

Background

A high-frequency point-of-care (POC) ultrasound instrument was used to evaluate the microstructural and biomechanical properties of the anterior sclera in vivo using parameters computed from quantitative ultrasound (QUS) methods.

Methods

In this cross-sectional study, both eyes of 85 enrolled patients were scanned with the POC instrument and ultrasound data were processed to obtain QUS parameters. Pearson correlation and multi-linear regression were used to identify relationships between QUS parameters and refractive error (RE) or axial length. After categorising eyes based on RE, binary support vector machine (SVM) classifiers were trained using the QUS or ophthalmic parameters (anterior chamber depth, central corneal thickness, corneal power, and intraocular pressure) to classify each eye. Classifier performance was evaluated by computing the area under the receiver-operating characteristic curve (AUC).

Results

Individual QUS parameters correlated with RE and axial length (p < 0.05). Multi-linear regression revealed significant correlation between the set of QUS parameters and both RE (R = 0.49, p < 0.001) and axial length (R = 0.46, p = 0.001). Classifiers trained with QUS parameters achieved higher AUC (𝑝 = 0.06) for identifying myopic eyes (AUC = 0.71) compared to classifiers trained with ophthalmic parameters (AUC = 0.63). QUS-based classifiers attained the highest AUC when identifying highly myopic eyes (AUC = 0.77).

Conclusions

QUS parameters correlate with progressing myopia and may be indicative of myopia-induced microstructural and biomechanical changes in the anterior sclera. These methods may provide critical clinical information complementary to standard ophthalmic measurements for predicting myopia progression and risk assessment for posterior staphyloma formation.

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来源期刊
CiteScore
7.60
自引率
12.50%
发文量
150
审稿时长
4-8 weeks
期刊介绍: Clinical & Experimental Ophthalmology is the official journal of The Royal Australian and New Zealand College of Ophthalmologists. The journal publishes peer-reviewed original research and reviews dealing with all aspects of clinical practice and research which are international in scope and application. CEO recognises the importance of collaborative research and welcomes papers that have a direct influence on ophthalmic practice but are not unique to ophthalmology.
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