{"title":"评估常规抗凝治疗后的急性缺血性脑卒中:直接口服抗凝剂与华法林治疗效果比较分析","authors":"Sumeyye Cakmak, Ruken Simsekoglu","doi":"10.1155/2024/7676634","DOIUrl":null,"url":null,"abstract":"<div>\n <p><i>Objective</i>. We aim to compare the outcomes between acute ischemic stroke (AIS) patients under vitamin K antagonist with those under direct oral anticoagulants (DOACs). <i>Methods</i>. This prospective, cross-sectional study was conducted for one year in a tertiary hospital operating as a stroke center. A total of 135 patients receiving oral anticoagulants (DOACs: 98 and VKA: 37) with AIS were included in the study. The patients’ vital parameters, examination and laboratory findings, acute stroke severity scores, stroke localizations, and 3-month clinical outcomes were recorded. <i>Results</i>. Of the 135 patients, 98 (mean age: 76.2, 52 women) were on DOACs while 37 (mean age: 69.7, 26 women) were on VKA. The average age was significantly higher in the group of patients receiving DOACs (<i>p</i> = 0.005). Although the mean age of the patient group using DOACs was higher, they did not score worse than patients using VKAs in terms of stroke severity and 3-month outcomes were equal in both groups. The rates of receiving iv-tPA (8.2% and 2.7%, respectively) and thrombectomy rates (23.5% and 29.7%, respectively) were low in the DOACs and VKA groups. <i>Conclusion</i>. The equality in stroke severity and 3-month outcome scores between the DOACs group, characterized by higher average age, and the VKA group is indicative of the comparable efficacy of DOACs in stroke management.</p>\n </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7676634","citationCount":"0","resultStr":"{\"title\":\"Evaluating Acute Ischemic Strokes despite Regular Anticoagulation: A Comparative Analysis of Direct Oral Anticoagulants and Warfarin in Treatment Outcomes\",\"authors\":\"Sumeyye Cakmak, Ruken Simsekoglu\",\"doi\":\"10.1155/2024/7676634\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n <p><i>Objective</i>. We aim to compare the outcomes between acute ischemic stroke (AIS) patients under vitamin K antagonist with those under direct oral anticoagulants (DOACs). <i>Methods</i>. This prospective, cross-sectional study was conducted for one year in a tertiary hospital operating as a stroke center. A total of 135 patients receiving oral anticoagulants (DOACs: 98 and VKA: 37) with AIS were included in the study. The patients’ vital parameters, examination and laboratory findings, acute stroke severity scores, stroke localizations, and 3-month clinical outcomes were recorded. <i>Results</i>. Of the 135 patients, 98 (mean age: 76.2, 52 women) were on DOACs while 37 (mean age: 69.7, 26 women) were on VKA. The average age was significantly higher in the group of patients receiving DOACs (<i>p</i> = 0.005). Although the mean age of the patient group using DOACs was higher, they did not score worse than patients using VKAs in terms of stroke severity and 3-month outcomes were equal in both groups. The rates of receiving iv-tPA (8.2% and 2.7%, respectively) and thrombectomy rates (23.5% and 29.7%, respectively) were low in the DOACs and VKA groups. <i>Conclusion</i>. The equality in stroke severity and 3-month outcome scores between the DOACs group, characterized by higher average age, and the VKA group is indicative of the comparable efficacy of DOACs in stroke management.</p>\\n </div>\",\"PeriodicalId\":13782,\"journal\":{\"name\":\"International Journal of Clinical Practice\",\"volume\":\"2024 1\",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7676634\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Clinical Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1155/2024/7676634\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/2024/7676634","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Evaluating Acute Ischemic Strokes despite Regular Anticoagulation: A Comparative Analysis of Direct Oral Anticoagulants and Warfarin in Treatment Outcomes
Objective. We aim to compare the outcomes between acute ischemic stroke (AIS) patients under vitamin K antagonist with those under direct oral anticoagulants (DOACs). Methods. This prospective, cross-sectional study was conducted for one year in a tertiary hospital operating as a stroke center. A total of 135 patients receiving oral anticoagulants (DOACs: 98 and VKA: 37) with AIS were included in the study. The patients’ vital parameters, examination and laboratory findings, acute stroke severity scores, stroke localizations, and 3-month clinical outcomes were recorded. Results. Of the 135 patients, 98 (mean age: 76.2, 52 women) were on DOACs while 37 (mean age: 69.7, 26 women) were on VKA. The average age was significantly higher in the group of patients receiving DOACs (p = 0.005). Although the mean age of the patient group using DOACs was higher, they did not score worse than patients using VKAs in terms of stroke severity and 3-month outcomes were equal in both groups. The rates of receiving iv-tPA (8.2% and 2.7%, respectively) and thrombectomy rates (23.5% and 29.7%, respectively) were low in the DOACs and VKA groups. Conclusion. The equality in stroke severity and 3-month outcome scores between the DOACs group, characterized by higher average age, and the VKA group is indicative of the comparable efficacy of DOACs in stroke management.
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