Zoran Gluvic , Milan Obradovic , Mia Manojlovic , Rosaria Vincenza Giglio , Angelo Maria Patti , Marcello Ciaccio , Jasjit S. Suri , Manfredi Rizzo , Esma R. Isenovic
{"title":"不同激素对糖尿病患者一氧化氮调节的影响。","authors":"Zoran Gluvic , Milan Obradovic , Mia Manojlovic , Rosaria Vincenza Giglio , Angelo Maria Patti , Marcello Ciaccio , Jasjit S. Suri , Manfredi Rizzo , Esma R. Isenovic","doi":"10.1016/j.mce.2024.112325","DOIUrl":null,"url":null,"abstract":"<div><p>Polymetabolic syndrome achieved pandemic proportions and dramatically influenced public health systems functioning worldwide. Chronic vascular complications are the major contributors to increased morbidity, disability, and mortality rates in diabetes patients. Nitric oxide (NO) is among the most important vascular bed function regulators. However, NO homeostasis is significantly deranged in pathological conditions. Additionally, different hormones directly or indirectly affect NO production and activity and subsequently act on vascular physiology. In this paper, we summarize the recent literature data related to the effects of insulin, estradiol, insulin-like growth factor-1, ghrelin, angiotensin II and irisin on the NO regulation in physiological and diabetes circumstances.</p></div>","PeriodicalId":18707,"journal":{"name":"Molecular and Cellular Endocrinology","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of different hormones on the regulation of nitric oxide in diabetes\",\"authors\":\"Zoran Gluvic , Milan Obradovic , Mia Manojlovic , Rosaria Vincenza Giglio , Angelo Maria Patti , Marcello Ciaccio , Jasjit S. Suri , Manfredi Rizzo , Esma R. Isenovic\",\"doi\":\"10.1016/j.mce.2024.112325\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Polymetabolic syndrome achieved pandemic proportions and dramatically influenced public health systems functioning worldwide. Chronic vascular complications are the major contributors to increased morbidity, disability, and mortality rates in diabetes patients. Nitric oxide (NO) is among the most important vascular bed function regulators. However, NO homeostasis is significantly deranged in pathological conditions. Additionally, different hormones directly or indirectly affect NO production and activity and subsequently act on vascular physiology. In this paper, we summarize the recent literature data related to the effects of insulin, estradiol, insulin-like growth factor-1, ghrelin, angiotensin II and irisin on the NO regulation in physiological and diabetes circumstances.</p></div>\",\"PeriodicalId\":18707,\"journal\":{\"name\":\"Molecular and Cellular Endocrinology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular and Cellular Endocrinology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0303720724001813\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular and Cellular Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0303720724001813","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
多代谢综合征已成为大流行病,对全球公共卫生系统的运作产生了巨大影响。慢性血管并发症是导致糖尿病患者发病率、残疾率和死亡率增加的主要原因。一氧化氮(NO)是最重要的血管床功能调节剂之一。然而,在病理情况下,一氧化氮的平衡会受到严重破坏。此外,不同的激素会直接或间接影响一氧化氮的产生和活性,进而影响血管生理。本文总结了最近有关胰岛素、雌二醇、胰岛素样生长因子-1 和鸢尾素在生理和糖尿病情况下对 NO 调节作用的文献数据。
Impact of different hormones on the regulation of nitric oxide in diabetes
Polymetabolic syndrome achieved pandemic proportions and dramatically influenced public health systems functioning worldwide. Chronic vascular complications are the major contributors to increased morbidity, disability, and mortality rates in diabetes patients. Nitric oxide (NO) is among the most important vascular bed function regulators. However, NO homeostasis is significantly deranged in pathological conditions. Additionally, different hormones directly or indirectly affect NO production and activity and subsequently act on vascular physiology. In this paper, we summarize the recent literature data related to the effects of insulin, estradiol, insulin-like growth factor-1, ghrelin, angiotensin II and irisin on the NO regulation in physiological and diabetes circumstances.
期刊介绍:
Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.