Alfonso Fasano , Hideo Mure , Genko Oyama , Nagako Murase , Thomas Witt , Yoshinori Higuchi , Alexa Singer , Claudia Sannelli , Nathan Morelli , on behalf of the DBS PSR Study Group
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Peak and band power measures were calculated from each recording.</p></div><div><h3>Results</h3><p>After bilateral LFP recordings, at least one peak was detected in 18 (81.8%), 20 (90.9%), and 22 (100%) patients at visit 1, 2, and 3, respectively. No significant differences were seen in primary peak amplitude (F = 2.91, <em>p</em> = 0.060) over time. Amplitude of the second largest peak (F = 5.49, <em>p</em> = 0.006) and low-beta (F = 6.89, <em>p</em> = 0.002), high-beta (F = 13.23, <em>p</em> < 0.001), and gamma (F = 12.71, p < 0.001) band power demonstrated a significant effect of time. Post hoc comparisons determined low-beta power (Visit 1–Visit 2: <em>t</em> = 3.59, p = 0.002; Visit 1–Visit 3: <em>t</em> = 2.61, <em>p</em> = 0.031), high-beta (Visit 1–Visit 2: <em>t</em> = 4.64, <em>p</em> < 0.001; Visit 1–Visit 3: <em>t</em> = 4.23, p < 0.001) and gamma band power (Visit 1–Visit 2: <em>t</em> = 4.65, p < 0.001; Visit 1–Visit 3: <em>t</em> = 4.00, p < 0.001) were significantly increased from visit 1 recordings to both follow-up visits.</p></div><div><h3>Conclusion</h3><p>Our results provide substantial evidence that LFP can reliably be detected across multiple real-world clinical visits in patients with STN-DBS for PD. Moreover, it provides insights on the evolution of these LFPs.</p></div>","PeriodicalId":19097,"journal":{"name":"Neurobiology of Disease","volume":null,"pages":null},"PeriodicalIF":5.1000,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S096999612400189X/pdfft?md5=f6441d8c4ac9f4cbe01e28af003ab8e7&pid=1-s2.0-S096999612400189X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Subthalamic nucleus local field potential stability in patients with Parkinson's disease\",\"authors\":\"Alfonso Fasano , Hideo Mure , Genko Oyama , Nagako Murase , Thomas Witt , Yoshinori Higuchi , Alexa Singer , Claudia Sannelli , Nathan Morelli , on behalf of the DBS PSR Study Group\",\"doi\":\"10.1016/j.nbd.2024.106589\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Despite the large body of work on local field potentials (LFPs), a measure of oscillatory activity in patients with Parkinson's disease (PD), the longitudinal evolution of LFPs is less explored.</p></div><div><h3>Objective</h3><p>To determine LFP fluctuations collected in clinical settings in patients with PD and STN deep brain stimulation (DBS).</p></div><div><h3>Methods</h3><p>Twenty-two STN-DBS patients (age: 67.6 ± 8.3 years; 9 females; disease duration: 10.3 ± 4.5 years) completed bilateral LFP recordings over three visits in the OFF-stimulation setting. Peak and band power measures were calculated from each recording.</p></div><div><h3>Results</h3><p>After bilateral LFP recordings, at least one peak was detected in 18 (81.8%), 20 (90.9%), and 22 (100%) patients at visit 1, 2, and 3, respectively. No significant differences were seen in primary peak amplitude (F = 2.91, <em>p</em> = 0.060) over time. Amplitude of the second largest peak (F = 5.49, <em>p</em> = 0.006) and low-beta (F = 6.89, <em>p</em> = 0.002), high-beta (F = 13.23, <em>p</em> < 0.001), and gamma (F = 12.71, p < 0.001) band power demonstrated a significant effect of time. Post hoc comparisons determined low-beta power (Visit 1–Visit 2: <em>t</em> = 3.59, p = 0.002; Visit 1–Visit 3: <em>t</em> = 2.61, <em>p</em> = 0.031), high-beta (Visit 1–Visit 2: <em>t</em> = 4.64, <em>p</em> < 0.001; Visit 1–Visit 3: <em>t</em> = 4.23, p < 0.001) and gamma band power (Visit 1–Visit 2: <em>t</em> = 4.65, p < 0.001; Visit 1–Visit 3: <em>t</em> = 4.00, p < 0.001) were significantly increased from visit 1 recordings to both follow-up visits.</p></div><div><h3>Conclusion</h3><p>Our results provide substantial evidence that LFP can reliably be detected across multiple real-world clinical visits in patients with STN-DBS for PD. 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Subthalamic nucleus local field potential stability in patients with Parkinson's disease
Background
Despite the large body of work on local field potentials (LFPs), a measure of oscillatory activity in patients with Parkinson's disease (PD), the longitudinal evolution of LFPs is less explored.
Objective
To determine LFP fluctuations collected in clinical settings in patients with PD and STN deep brain stimulation (DBS).
Methods
Twenty-two STN-DBS patients (age: 67.6 ± 8.3 years; 9 females; disease duration: 10.3 ± 4.5 years) completed bilateral LFP recordings over three visits in the OFF-stimulation setting. Peak and band power measures were calculated from each recording.
Results
After bilateral LFP recordings, at least one peak was detected in 18 (81.8%), 20 (90.9%), and 22 (100%) patients at visit 1, 2, and 3, respectively. No significant differences were seen in primary peak amplitude (F = 2.91, p = 0.060) over time. Amplitude of the second largest peak (F = 5.49, p = 0.006) and low-beta (F = 6.89, p = 0.002), high-beta (F = 13.23, p < 0.001), and gamma (F = 12.71, p < 0.001) band power demonstrated a significant effect of time. Post hoc comparisons determined low-beta power (Visit 1–Visit 2: t = 3.59, p = 0.002; Visit 1–Visit 3: t = 2.61, p = 0.031), high-beta (Visit 1–Visit 2: t = 4.64, p < 0.001; Visit 1–Visit 3: t = 4.23, p < 0.001) and gamma band power (Visit 1–Visit 2: t = 4.65, p < 0.001; Visit 1–Visit 3: t = 4.00, p < 0.001) were significantly increased from visit 1 recordings to both follow-up visits.
Conclusion
Our results provide substantial evidence that LFP can reliably be detected across multiple real-world clinical visits in patients with STN-DBS for PD. Moreover, it provides insights on the evolution of these LFPs.
期刊介绍:
Neurobiology of Disease is a major international journal at the interface between basic and clinical neuroscience. The journal provides a forum for the publication of top quality research papers on: molecular and cellular definitions of disease mechanisms, the neural systems and underpinning behavioral disorders, the genetics of inherited neurological and psychiatric diseases, nervous system aging, and findings relevant to the development of new therapies.