移植中的 HHV-8 相关疾病：以诊断和预防为重点的病例报告和叙述性综述。

IF 2.6 4区医学 Q3 IMMUNOLOGY Transplant Infectious Disease Pub Date : 2024-11-01 Epub Date: 2024-07-07 DOI:10.1111/tid.14334

Olivia S Kates, Heather McDade, Francis J Tinney, Sharon R Weeks-Groh, Kathryn Lurain

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引用次数: 0

摘要

背景：人类疱疹病毒8（HHV-8）或卡波西肉瘤疱疹病毒（KSHV）是一种机会性肿瘤病毒，可导致多种病理实体：我们报告了一例致命的 HHV-8 相关多系统疾病，伴有播散性卡波西肉瘤和 HHV8 相关淋巴组织增生性疾病及全身炎症。我们对有关移植中 HHV-8 的文献进行了叙述性综述，旨在阐明这一易感人群中 HHV-8 相关疾病的范围、疾病传播方式以及供体和受体筛查的潜在作用：结果：与HHV-8相关的KS、原发性渗出淋巴瘤（PEL）、多中心卡斯特曼病（MCD）和KSHV炎性细胞因子紊乱（KICS）可能会影响移植受者；除KS外，这些疾病都很罕见，但发病率和死亡率都很高：结论：HHV-8相关疾病在移植受者中的表现多种多样，而且很复杂，有可能造成致命后果。器官捐献者中的 HHV-8 血清流行率以及捐献者感染 HHV-8 或发生临床重大疾病的风险程度仍是未知数，需要进一步研究。

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HHV-8-associated diseases in transplantation: A case report and narrative review focused on diagnosis and prevention.

Background: Human herpes virus 8 (HHV-8) or Kaposi sarcoma herpesvirus (KSHV) is an opportunistic oncovirus that causes multiple pathologic entities.

Methods: We present a case of fatal HHV-8-associated multisystem illness with disseminated Kaposi sarcoma and HHV8-associated lymphoproliferative disorder with systemic inflammation. We conducted a narrative review of the literature on HHV-8 in transplantation with a goal of illuminating the spectrum of HHV-8-associated diseases in this vulnerable population, modes of disease transmission, and the potential role for donor and recipient screening.

Results: HHV-8-associated KS, primary effusion lymphoma (PEL), multicentric Castleman disease (MCD), and KSHV inflammatory cytokine disorder (KICS) may affect transplant recipients; with the exception of KS, these conditions are rare but carry high morbidity and mortality.

Conclusion: HHV-8-associated diseases have diverse and protean manifestations in transplant recipients, with potentially fatal outcomes. HHV-8 seroprevalence among organ donors and the magnitude of risk for donor-derived HHV-8 infection or clinically significant disease remain unknown and require further study.

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来源期刊

Transplant Infectious Disease 医学-传染病学

CiteScore

5.30

自引率

7.70%

发文量

210

审稿时长

4-8 weeks

期刊介绍： Transplant Infectious Disease has been established as a forum for presenting the most current information on the prevention and treatment of infection complicating organ and bone marrow transplantation. The point of view of the journal is that infection and allograft rejection (or graft-versus-host disease) are closely intertwined, and that advances in one area will have immediate consequences on the other. The interaction of the transplant recipient with potential microbial invaders, the impact of immunosuppressive strategies on this interaction, and the effects of cytokines, growth factors, and chemokines liberated during the course of infections, rejection, or graft-versus-host disease are central to the interests and mission of this journal. Transplant Infectious Disease is aimed at disseminating the latest information relevant to the infectious disease complications of transplantation to clinicians and scientists involved in bone marrow, kidney, liver, heart, lung, intestinal, and pancreatic transplantation. The infectious disease consequences and concerns regarding innovative transplant strategies, from novel immunosuppressive agents to xenotransplantation, are very much a concern of this journal. In addition, this journal feels a particular responsibility to inform primary care practitioners in the community, who increasingly are sharing the responsibility for the care of these patients, of the special considerations regarding the prevention and treatment of infection in transplant recipients. As exemplified by the international editorial board, articles are sought throughout the world that address both general issues and those of a more restricted geographic import.