母体疾病与后代肾脏和泌尿道先天性异常:一项队列研究。

IF 6.1 2区 医学 Q1 PEDIATRICS World Journal of Pediatrics Pub Date : 2024-11-01 Epub Date: 2024-07-06 DOI:10.1007/s12519-024-00822-1
Qiang Ma, Ya-Qi Li, Qing-Tang Meng, Bo Yang, Hai-Tao Zhang, Hua Shi, Chang-You Liu, Tian-Chao Xiang, Na Zhao, Jia Rao
{"title":"母体疾病与后代肾脏和泌尿道先天性异常:一项队列研究。","authors":"Qiang Ma, Ya-Qi Li, Qing-Tang Meng, Bo Yang, Hai-Tao Zhang, Hua Shi, Chang-You Liu, Tian-Chao Xiang, Na Zhao, Jia Rao","doi":"10.1007/s12519-024-00822-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Congenital anomalies of the kidneys and urinary tract (CAKUT) are the most common cause of prenatally diagnosed developmental malformation. This study aimed to assess the relationship between maternal diseases and CAKUT in offspring.</p><p><strong>Methods: </strong>This retrospective study enrolled all pregnant women registered from January 2020 to December 2022 at one medical center. Medical information on maternal noncommunicable diseases, including obesity, hypertension, diabetes mellitus, kidney disease, hyperthyroidism, hypothyroidism, psychiatric disease, epilepsy, cancer, and autoimmune disease was collected. Based on the records of ultrasound scanning during the third trimester, the diagnosis was classified as isolated urinary tract dilation (UTD) or kidney anomalies. Multivariate logistic regression was performed to establish models to predict antenatal CAKUT.</p><p><strong>Results: </strong>Among the 19,656 pregnant women, perinatal ultrasound detected suspicious CAKUT in 114 (5.8/1000) fetuses, comprising 89 cases with isolated UTD and 25 cases with kidney anomalies. The risk of antenatal CAKUT was increased in the fetuses of mothers who experienced gestational diabetes, thyroid dysfunction, neuropsychiatric disease, anemia, ovarian and uterine disorders. A prediction model for isolated UTD was developed utilizing four confounding factors, namely gestational diabetes, gestational hypertension, maternal thyroid dysfunction, and hepatic disease. Similarly, a separate prediction model for kidney anomalies was established based on four distinct confounding factors, namely maternal thyroid dysfunction, gestational diabetes, disorders of ovarian/uterine, and kidney disease.</p><p><strong>Conclusions: </strong>Isolated UTD and kidney anomalies were associated with different maternal diseases. The results may inform the clinical management of pregnancy and highlight potential differences in the genesis of various subtypes of CAKUT.</p>","PeriodicalId":23883,"journal":{"name":"World Journal of Pediatrics","volume":" ","pages":"1168-1178"},"PeriodicalIF":6.1000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582095/pdf/","citationCount":"0","resultStr":"{\"title\":\"Maternal diseases and congenital anomalies of the kidney and urinary tract in offspring: a cohort study.\",\"authors\":\"Qiang Ma, Ya-Qi Li, Qing-Tang Meng, Bo Yang, Hai-Tao Zhang, Hua Shi, Chang-You Liu, Tian-Chao Xiang, Na Zhao, Jia Rao\",\"doi\":\"10.1007/s12519-024-00822-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Congenital anomalies of the kidneys and urinary tract (CAKUT) are the most common cause of prenatally diagnosed developmental malformation. This study aimed to assess the relationship between maternal diseases and CAKUT in offspring.</p><p><strong>Methods: </strong>This retrospective study enrolled all pregnant women registered from January 2020 to December 2022 at one medical center. Medical information on maternal noncommunicable diseases, including obesity, hypertension, diabetes mellitus, kidney disease, hyperthyroidism, hypothyroidism, psychiatric disease, epilepsy, cancer, and autoimmune disease was collected. Based on the records of ultrasound scanning during the third trimester, the diagnosis was classified as isolated urinary tract dilation (UTD) or kidney anomalies. Multivariate logistic regression was performed to establish models to predict antenatal CAKUT.</p><p><strong>Results: </strong>Among the 19,656 pregnant women, perinatal ultrasound detected suspicious CAKUT in 114 (5.8/1000) fetuses, comprising 89 cases with isolated UTD and 25 cases with kidney anomalies. The risk of antenatal CAKUT was increased in the fetuses of mothers who experienced gestational diabetes, thyroid dysfunction, neuropsychiatric disease, anemia, ovarian and uterine disorders. A prediction model for isolated UTD was developed utilizing four confounding factors, namely gestational diabetes, gestational hypertension, maternal thyroid dysfunction, and hepatic disease. Similarly, a separate prediction model for kidney anomalies was established based on four distinct confounding factors, namely maternal thyroid dysfunction, gestational diabetes, disorders of ovarian/uterine, and kidney disease.</p><p><strong>Conclusions: </strong>Isolated UTD and kidney anomalies were associated with different maternal diseases. The results may inform the clinical management of pregnancy and highlight potential differences in the genesis of various subtypes of CAKUT.</p>\",\"PeriodicalId\":23883,\"journal\":{\"name\":\"World Journal of Pediatrics\",\"volume\":\" \",\"pages\":\"1168-1178\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582095/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Journal of Pediatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12519-024-00822-1\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12519-024-00822-1","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/6 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

摘要

背景:先天性肾脏和泌尿道畸形(CAKUT)是产前诊断为发育畸形的最常见原因。本研究旨在评估母体疾病与后代先天性肾脏和尿路畸形之间的关系:这项回顾性研究登记了一家医疗中心 2020 年 1 月至 2022 年 12 月期间登记的所有孕妇。收集了孕产妇非传染性疾病的医疗信息,包括肥胖、高血压、糖尿病、肾脏疾病、甲状腺功能亢进、甲状腺功能减退、精神疾病、癫痫、癌症和自身免疫性疾病。根据怀孕三个月时的超声波扫描记录,诊断结果分为孤立性尿路扩张(UTD)或肾脏异常。通过多变量逻辑回归建立了预测产前 CAKUT 的模型:结果:在19656名孕妇中,围产期超声检查发现了114个可疑CAKUT胎儿(5.8/1000),其中89例为孤立性UTD,25例为肾脏异常。母亲患有妊娠糖尿病、甲状腺功能障碍、神经精神疾病、贫血、卵巢和子宫疾病的,其胎儿在产前发生 CAKUT 的风险会增加。利用四个混杂因素,即妊娠糖尿病、妊娠高血压、母体甲状腺功能障碍和肝病,建立了一个孤立UTD预测模型。同样,根据四个不同的混杂因素,即母体甲状腺功能障碍、妊娠糖尿病、卵巢/子宫疾病和肾脏疾病,建立了一个单独的肾脏异常预测模型:孤立的UTD和肾脏异常与不同的母体疾病有关。结论:孤立性UTD和肾脏异常与不同的孕产妇疾病有关,这些结果可为妊娠的临床管理提供参考,并强调了各种亚型CAKUT的潜在成因差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Maternal diseases and congenital anomalies of the kidney and urinary tract in offspring: a cohort study.

Background: Congenital anomalies of the kidneys and urinary tract (CAKUT) are the most common cause of prenatally diagnosed developmental malformation. This study aimed to assess the relationship between maternal diseases and CAKUT in offspring.

Methods: This retrospective study enrolled all pregnant women registered from January 2020 to December 2022 at one medical center. Medical information on maternal noncommunicable diseases, including obesity, hypertension, diabetes mellitus, kidney disease, hyperthyroidism, hypothyroidism, psychiatric disease, epilepsy, cancer, and autoimmune disease was collected. Based on the records of ultrasound scanning during the third trimester, the diagnosis was classified as isolated urinary tract dilation (UTD) or kidney anomalies. Multivariate logistic regression was performed to establish models to predict antenatal CAKUT.

Results: Among the 19,656 pregnant women, perinatal ultrasound detected suspicious CAKUT in 114 (5.8/1000) fetuses, comprising 89 cases with isolated UTD and 25 cases with kidney anomalies. The risk of antenatal CAKUT was increased in the fetuses of mothers who experienced gestational diabetes, thyroid dysfunction, neuropsychiatric disease, anemia, ovarian and uterine disorders. A prediction model for isolated UTD was developed utilizing four confounding factors, namely gestational diabetes, gestational hypertension, maternal thyroid dysfunction, and hepatic disease. Similarly, a separate prediction model for kidney anomalies was established based on four distinct confounding factors, namely maternal thyroid dysfunction, gestational diabetes, disorders of ovarian/uterine, and kidney disease.

Conclusions: Isolated UTD and kidney anomalies were associated with different maternal diseases. The results may inform the clinical management of pregnancy and highlight potential differences in the genesis of various subtypes of CAKUT.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
World Journal of Pediatrics
World Journal of Pediatrics 医学-小儿科
CiteScore
10.50
自引率
1.10%
发文量
592
审稿时长
2.5 months
期刊介绍: The World Journal of Pediatrics, a monthly publication, is dedicated to disseminating peer-reviewed original papers, reviews, and special reports focusing on clinical practice and research in pediatrics. We welcome contributions from pediatricians worldwide on new developments across all areas of pediatrics, including pediatric surgery, preventive healthcare, pharmacology, stomatology, and biomedicine. The journal also covers basic sciences and experimental work, serving as a comprehensive academic platform for the international exchange of medical findings.
期刊最新文献
Fecal microbiota transplants in pediatric autism: opportunities and challenges. Impact of serial clinical swallow evaluations and feeding interventions on growth and feeding outcomes in children with long-gap esophageal atresia after anastomosis: a retrospective cohort study. Expert consensus for pertussis in children: new concepts in diagnosis and treatment. Associations between the prevalence of asthma and dietary exposure to food contaminants in children: CHASER study. Correction: Longer duration of initial invasive mechanical ventilation is still a crucial risk factor for moderate-to-severe bronchopulmonary dysplasia in very preterm infants: a multicentrer prospective study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1