猴子看,猴子干:跟踪 iPS 心肌细胞在自体移植物中的存活和成熟。

Xiaoqian Ji, Qiyuan Wang, Nan Cao
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摘要

诱导多能干细胞衍生心肌细胞(iPSC-CM)疗法已成为极具前景的心脏修复领域。Lin等人1提出了令人信服的证据,证明自体iPSC-CMs在两只猕猴体内的长期移植和成熟,在大型动物模型中展示了前所未有的心脏自体移植数据,且无需使用免疫抑制剂。
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Monkey see, monkey do: Tracking iPS-cardiomyocyte survival and maturation in autografts.

Induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) therapy has emerged as a highly promising field of heart repair. Lin et al.1 presented compelling evidence on the long-term engraftment and maturation of autologous iPSC-CMs in two rhesus macaques, demonstrating unprecedented cardiac autografting data in large animal models without the need of immunosuppressants.

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