带坏死核心的肿瘤生长是压力的一个障碍问题

IF 1.2 4区 数学 Q2 MATHEMATICS, APPLIED Acta Applicandae Mathematicae Pub Date : 2024-06-07 DOI:10.1007/s10440-024-00664-z
Xu’an Dou, Chengfeng Shen, Zhennan Zhou
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引用次数: 0

摘要

受细胞密度模型不可压缩极限的启发,我们提出了一种自由边界肿瘤生长模型,在该模型中,压力满足演化域 \(\Omega (t)\) 上的障碍问题,而重合集 \(\Lambda (t)\) 捕捉到了新出现的坏死核心。我们从以下两个方面对解法结构的分析特征做出了贡献。通过推导半解析解并研究其动力学行为,我们得到了坏死核心发展过程中解体分离阶段的定量过渡特性,并建立了其与行波解的长时间极限。此外,我们还证明了包含肿瘤体外非零外密度的行波解的存在,前提是外密度的大小低于临界值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Tumor Growth with a Necrotic Core as an Obstacle Problem in Pressure

Motivated by the incompressible limit of a cell density model, we propose a free boundary tumor growth model where the pressure satisfies an obstacle problem on an evolving domain \(\Omega (t)\), and the coincidence set \(\Lambda (t)\) captures the emerging necrotic core. We contribute to the analytical characterization of the solution structure in the following two aspects. By deriving a semi-analytical solution and studying its dynamical behavior, we obtain quantitative transitional properties of the solution separating phases in the development of necrotic cores and establish its long time limit with the traveling wave solutions. Also, we prove the existence of traveling wave solutions incorporating non-zero outer densities outside the tumor bulk, provided that the size of the outer density is below a threshold.

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来源期刊
Acta Applicandae Mathematicae
Acta Applicandae Mathematicae 数学-应用数学
CiteScore
2.80
自引率
6.20%
发文量
77
审稿时长
16.2 months
期刊介绍: Acta Applicandae Mathematicae is devoted to the art and techniques of applying mathematics and the development of new, applicable mathematical methods. Covering a large spectrum from modeling to qualitative analysis and computational methods, Acta Applicandae Mathematicae contains papers on different aspects of the relationship between theory and applications, ranging from descriptive papers on actual applications meeting contemporary mathematical standards to proofs of new and deep theorems in applied mathematics.
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