辣椒素作用下嘌呤能调节肌神经递质的模式

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2024-07-04 DOI:10.1134/S0006350924700131

A. E. Khairullin, M. A. Mukhamedyarov, R. D. Mukhamedzyanov, N. M. Kashtanova, E. N. Zhivotova, G. G. Suchkova, A. R. Shaikhutdinova, A. A. Eremeev, S. N. Grishin

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引用次数: 0

摘要

辣椒素是痛觉刺激的整合剂，会引起热感，本研究旨在研究辣椒素存在时的肌神经传导。研究还探讨了参与突触传递的嘌呤（如 ATP 和腺苷）在辣椒素作用下的影响。当用含有辣椒素的溶液灌注蛙的神经肌肉制剂时，这两种嘌呤的抑制作用明显减弱。腺苷抑制作用的降低与 A1 信号的抑制有关，因为 A2A 受体激动剂 CGS21680 在辣椒素存在的情况下显示出明显的增效作用，而对照组几乎完全没有这种作用。我们的研究结果表明，已知的辣椒素神经保护作用主要是由于消除了内源性嘌呤对神经递质诱导量子输出的抑制。

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Patterns of Purinergic Modulation of Myoneural Transmission in Presence of Capsaicin

This study aimed to investigate myoneural transmission in the presence of capsaicin, which acts as an integrator of pain stimuli and causes heat sensation. The effects of purines that participate in synaptic transmission, such as ATP and adenosine, in the presence of capsaicin were explored. When the neuromuscular preparation of frog was perfused with solution containing capsaicin, the inhibitory effects of both purines were significantly reduced. A reduction of the depressant effects of adenosine is associated with the inhibition of A₁ signaling, since the A_2A receptor agonist CGS21680 showed a pronounced potentiating effect in the presence of capsaicin, which was almost completely hidden in the control. Our findings suggest that the known neuroprotective effect of capsaicin is primarily due to elimination of inhibition by endogenous purines of the induced quantum output of the neurotransmitter.

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.