{"title":"实验室合成的 MgGA Bio-MOF 作为抗氧化剂和药物载体的生物药效评估","authors":"Manu Sharma, Gagandeep Kaur, Pawan Kumar","doi":"10.1007/s10876-024-02650-9","DOIUrl":null,"url":null,"abstract":"<div><p>In this work, a magnesium-based biomolecule metal organic framework (MgGA Bio-MOF) has been synthesized using magnesium chloride hexahydrate (MgCl<sub>2</sub>.6H<sub>2</sub>O) as a metal cation and an edible linker gallic acid (GA, C<sub>6</sub>H<sub>2</sub>(OH)<sub>3</sub>CO<sub>2</sub>H) as a organic building unit in water under certain experimental conditions. Initially, MgGA Bio-MOF synthesis has been confirmed through spectroscopic and microscopic analysis techniques. Afterwards, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay has been performed to know the antioxidant activity of MOF. From the DPPH assay, it has been found that MgGA Bio-MOF possesses 70.4% scavenging activity. To proceed further, the drug release studies have been performed through IBU@MgGA Bio-MOF conjugate using UV- vis spectroscopy In investigation of drug release studies, we have observed 79% IBU released up to 150 min from IBU@MgGA Bio-MOF conjugate at neutral pH. After that, a constant absorbance has been observed, indicating the complete release of IBU. Overall, we found the selected BioMOF has excellent biological utility as an antioxidant agent as well as an anti-inflammatory drug carrier in line of its real-world applications</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 7","pages":"2243 - 2251"},"PeriodicalIF":2.7000,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biological Efficacy Evaluation of Lab Synthesized MgGA Bio-MOF as an Antioxidant Agent and Drug Vehicle\",\"authors\":\"Manu Sharma, Gagandeep Kaur, Pawan Kumar\",\"doi\":\"10.1007/s10876-024-02650-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this work, a magnesium-based biomolecule metal organic framework (MgGA Bio-MOF) has been synthesized using magnesium chloride hexahydrate (MgCl<sub>2</sub>.6H<sub>2</sub>O) as a metal cation and an edible linker gallic acid (GA, C<sub>6</sub>H<sub>2</sub>(OH)<sub>3</sub>CO<sub>2</sub>H) as a organic building unit in water under certain experimental conditions. Initially, MgGA Bio-MOF synthesis has been confirmed through spectroscopic and microscopic analysis techniques. Afterwards, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay has been performed to know the antioxidant activity of MOF. From the DPPH assay, it has been found that MgGA Bio-MOF possesses 70.4% scavenging activity. To proceed further, the drug release studies have been performed through IBU@MgGA Bio-MOF conjugate using UV- vis spectroscopy In investigation of drug release studies, we have observed 79% IBU released up to 150 min from IBU@MgGA Bio-MOF conjugate at neutral pH. After that, a constant absorbance has been observed, indicating the complete release of IBU. Overall, we found the selected BioMOF has excellent biological utility as an antioxidant agent as well as an anti-inflammatory drug carrier in line of its real-world applications</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":618,\"journal\":{\"name\":\"Journal of Cluster Science\",\"volume\":\"35 7\",\"pages\":\"2243 - 2251\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cluster Science\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10876-024-02650-9\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cluster Science","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10876-024-02650-9","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Biological Efficacy Evaluation of Lab Synthesized MgGA Bio-MOF as an Antioxidant Agent and Drug Vehicle
In this work, a magnesium-based biomolecule metal organic framework (MgGA Bio-MOF) has been synthesized using magnesium chloride hexahydrate (MgCl2.6H2O) as a metal cation and an edible linker gallic acid (GA, C6H2(OH)3CO2H) as a organic building unit in water under certain experimental conditions. Initially, MgGA Bio-MOF synthesis has been confirmed through spectroscopic and microscopic analysis techniques. Afterwards, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay has been performed to know the antioxidant activity of MOF. From the DPPH assay, it has been found that MgGA Bio-MOF possesses 70.4% scavenging activity. To proceed further, the drug release studies have been performed through IBU@MgGA Bio-MOF conjugate using UV- vis spectroscopy In investigation of drug release studies, we have observed 79% IBU released up to 150 min from IBU@MgGA Bio-MOF conjugate at neutral pH. After that, a constant absorbance has been observed, indicating the complete release of IBU. Overall, we found the selected BioMOF has excellent biological utility as an antioxidant agent as well as an anti-inflammatory drug carrier in line of its real-world applications
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