作为超级矮壮素的丁基羟基甲苯醌甲醚中毒：首例报告的人类病例。

IF 1.2 4区医学 Q4 HEMATOLOGY Blood Coagulation & Fibrinolysis Pub Date : 2024-07-01 Epub Date: 2024-05-09 DOI:10.1097/MBC.0000000000001307

Fehmi Hindilerden, Elif Aksoy, Asli Yüksel Öztürkmen, Gamze Türker, Emine Gültürk, Veysel Sabri Hançer, Selda Mercan

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引用次数: 0

摘要

超级矮壮素是一种抗凝血灭鼠剂，药效是母体化合物的近 100 倍。自超级矮壮素问世以来，已有意外和蓄意超级矮壮素中毒的报道。我们报告了首例丁基羟基甲苯（BHT）醌甲醚作为超级矮壮素引起的人类中毒事件，据报道，超级矮壮素是一种耐受性良好的食品添加剂和防腐剂，在各行各业中被用作抗氧化剂、稳定剂和抗剥皮剂。我们的目的是强调这种以前从未报道过的与 BHT 有关的人类潜在致命并发症的可能根本原因。

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Poisoning by butylated hydroxytoluene quinone methide acting as a superwarfarin: first reported case in humans.

Superwarfarins are anticoagulant rodenticides nearly 100-fold potent than the parent compound. Since their development, accidental and intentional cases of superwarfarin poisoning have been reported. We report the first human case of poisoning by butylated hydroxytoluene (BHT) quinone methide acting as a superwarfarin otherwise reported to be a well tolerated food additive and preservative and used as an antioxidant, stabilizer, anti-skinning agent in various industries. We aim to highlight the possible underlying cause of this previously unreported and potentially lethal BHT-related complication in the human.

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来源期刊

Blood Coagulation & Fibrinolysis 医学-血液学

CiteScore

1.90

自引率

0.00%

发文量

111

审稿时长

4-8 weeks

期刊介绍： Blood Coagulation & Fibrinolysis is an international fully refereed journal that features review and original research articles on all clinical, laboratory and experimental aspects of haemostasis and thrombosis. The journal is devoted to publishing significant developments worldwide in the field of blood coagulation, fibrinolysis, thrombosis, platelets and the kininogen-kinin system, as well as dealing with those aspects of blood rheology relevant to haemostasis and the effects of drugs on haemostatic components