炎症脂肪组织中的中性粒细胞迁移是由 VLA-6 介导的

IF 4.3 4区 医学 Q2 IMMUNOLOGY Immune Network Pub Date : 2024-05-31 eCollection Date: 2024-06-01 DOI:10.4110/in.2024.24.e23
Hyunseo Lim, Young Ho Choe, Jaeho Lee, Gi Eun Kim, Jin Won Hyun, Young-Min Hyun
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引用次数: 0

摘要

众所周知,脂肪组织具有内分泌功能,但它在体内也发挥着免疫作用。在 LPS 诱导的全身炎症中,发炎的脂肪组织的特点是促炎免疫细胞,尤其是中性粒细胞占主导地位。虽然已经发现巨噬细胞向受损或死亡的脂肪细胞迁移,在发炎的脂肪组织中形成冠状结构,但中性粒细胞与脂肪细胞或细胞外基质的相互作用仍然未知。在这里,我们证明了中性粒细胞的粘附分子,尤其是整合素α6β1参与了脂肪细胞或炎症脂肪组织细胞外基质的相互作用。这些结果表明,破坏脂肪组织成分与中性粒细胞之间的粘附可能会控制中性粒细胞在炎症组织中的过度聚集,这是通过抑制炎症免疫细胞开发抗炎疗法的先决条件。
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Neutrophil Migration Is Mediated by VLA-6 in the Inflamed Adipose Tissue.

Adipose tissue, well known for its endocrine function, plays an immunological role in the body. The inflamed adipose tissue under LPS-induced systemic inflammation is characterized by the dominance of pro-inflammatory immune cells, particularly neutrophils. Although migration of macrophages toward damaged or dead adipocytes to form a crown-like structure in inflamed adipose tissue has been revealed, the neutrophilic interaction with adipocytes or the extracellular matrix remains unknown. Here, we demonstrated the involvement of adhesion molecules, particularly integrin α6β1, of neutrophils in adipocytes or the extracellular matrix of inflamed adipose tissue interaction. These results suggest that disrupting the adhesion between adipose tissue components and neutrophils may govern the accumulation of excessive neutrophils in inflamed tissues, a prerequisite in developing anti-inflammatory therapeutics by inhibiting inflammatory immune cells.

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来源期刊
Immune Network
Immune Network Immunology and Microbiology-Immunology
CiteScore
2.90
自引率
3.30%
发文量
36
期刊介绍: Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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