接受体外受精的妇女的工作状况与临床妊娠和流产的关系:单中心横断面研究。

IF 2.3 Q2 OBSTETRICS & GYNECOLOGY International Journal of Fertility & Sterility Pub Date : 2024-06-09 DOI:10.22074/ijfs.2024.2008462.1507
Dinara Makhadiyeva, Almaz Ibragimov, Saltanat Baikoshkarova, Milan Terzic, Alpamys Issanov
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引用次数: 0

摘要

背景:在不孕不育诊所接受体外受精(IVF)治疗的患者中,中年职业女性占大多数。在这项研究中,我们旨在确定妇女的工作状况与试管婴儿治疗后头三个月临床妊娠和流产的关系:在哈萨克斯坦一家私人诊所进行的这项单中心横断面研究中,我们查阅了2018年1月至2019年12月期间所有试管婴儿卵胞浆内单精子注射(ICSI)和新鲜胚胎移植(ET)周期的电子病历(n=654)。研究选取了 300 例卵巢储备正常且医疗记录中登记有女性伴侣工作状态的患者的周期进行分析。研究的主要结局指标是前三个月的临床妊娠率和临床流产率。结果:204名女性在治疗开始前有工作,96名没有工作。所有患者的平均年龄为(32.2 ± 4.8)岁,从 23 岁到 46 岁不等。三分之二的职业女性从事医生、中小学和大学教师、会计、文员和经理等办公室职业。三分之一的研究参与者从事体力劳动,包括服务岗位和工厂工人。经年龄、前卵泡数、盆腔粘连溶解史和胚胎移植时的胚胎发育阶段调整后,妇女的工作状态与临床妊娠率之间没有关联。然而,与非职业女性相比,职业女性在妊娠头三个月流产的风险几乎是非职业女性的五倍[调整后的几率比(aOR)为 4.56,95% 置信区间(CI):0.52 至 4.96],并对年龄和取回的卵母细胞数量进行了调整:结论:在开始试管婴儿治疗前工作的妇女可以放心,与不工作的妇女相比,她们在治疗后有同等的受孕机会。观察到的职业女性怀孕头三个月流产的风险需要进一步研究,然后才能从医学和公共卫生角度得出结论。
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Association of Working Status with Clinical Pregnancy and Miscarriage among Women undergoing In Vitro Fertilization: Single-Centre Cross-Sectional Study.

Background: Middle-aged working women represent most patients attending fertility clinics for in vitro fertilization (IVF) treatment. In this study, we aimed to identify the association of women's working status with clinical pregnancy and miscarriage in the first trimester after IVF treatment.

Materials and methods: In this single-centre cross-sectional study at a private clinic in Kazakhstan, we reviewed electronic medical records of all IVF with intracytoplasmic sperm injection (ICSI) and fresh embryo transfer (ET) cycles from January 2018 to December 2019 (n=654). 300 cycles in patients with normal ovarian reserve and registered working status of a female partner in the medical records were selected for the analysis. The study's primary outcome measures were clinical pregnancy rates and clinical miscarriage in the first trimester.

Results: 204 women were employed, while 96 were not employed before the start of treatment. The mean age of all patients was 32.2 ± 4.8 years, ranging from 23 to 46 years. Two-thirds of working women had office-based occupations employed as doctors, school and university teachers, accountants, clerks, and managers. One-third of the study participants had manual labor jobs, including service positions and plant workers. There was no association between women's working status and clinical pregnancy rate adjusted for age, antral follicle count, history of pelvic adhesiolysis, and embryo development stage at embryo transfer. However, working women had almost five times the risk of the first trimester miscarriage compared to non-working women [adjusted odds ratio (aOR) 4.56, 95% confidence interval (CI): 0.52 to 4.96] adjusted for age and number of retrieved oocytes.

Conclusion: Women who work before commencing IVF treatment can be reassured of having equal chances of conception following the treatment compared to non-working women. The observed risk of first trimester miscarriage in working women necessitates further research before drawing any conclusions from medical and public health points.

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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.
期刊最新文献
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