氧化还原景观导航:活性氧对细胞周期的调控。

IF 5.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Report Pub Date : 2024-12-01 Epub Date: 2024-07-07 DOI:10.1080/13510002.2024.2371173
Viktoria Mackova, Martina Raudenska, Hana Holcova Polanska, Milan Jakubek, Michal Masarik
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引用次数: 0

摘要

目的:为了增进我们对疾病机理和治疗方案的了解,了解细胞周期调控至关重要。最近的研究强调了活性氧(ROS)在细胞周期调控中的重要性。虽然过高的 ROS 水平会导致与年龄相关的病症,但 ROS 在正常细胞功能中也发挥着至关重要的作用。许多细胞周期调控蛋白受其氧化还原状态的影响,但 ROS 促进或抑制细胞增殖的确切机制和条件尚未完全明了:本综述介绍了科学文献和公开数据库中有关细胞周期中氧化还原状态变化及其对关键调控蛋白影响的数据:我们确定了细胞周期机制中的氧化还原敏感靶标,并分析了 ROS(类型、浓度、暴露持续时间)对细胞周期各阶段的不同影响。例如,中等水平的氧化还原反应可通过激活细胞周期进展的信号通路促进细胞增殖,而过量的氧化还原反应则会诱发DNA损伤,引发细胞周期停滞或细胞死亡:我们的研究结果鼓励未来的研究重点放在确定细胞周期机制中对氧化还原反应敏感的靶点上,这有可能为细胞增殖失调疾病带来新的治疗方法。
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Navigating the redox landscape: reactive oxygen species in regulation of cell cycle.

Objectives: To advance our knowledge of disease mechanisms and therapeutic options, understanding cell cycle regulation is critical. Recent research has highlighted the importance of reactive oxygen species (ROS) in cell cycle regulation. Although excessive ROS levels can lead to age-related pathologies, ROS also play an essential role in normal cellular functions. Many cell cycle regulatory proteins are affected by their redox status, but the precise mechanisms and conditions under which ROS promote or inhibit cell proliferation are not fully understood.Methods: This review presents data from the scientific literature and publicly available databases on changes in redox state during the cell cycle and their effects on key regulatory proteins.Results: We identified redox-sensitive targets within the cell cycle machinery and analysed different effects of ROS (type, concentration, duration of exposure) on cell cycle phases. For example, moderate levels of ROS can promote cell proliferation by activating signalling pathways involved in cell cycle progression, whereas excessive ROS levels can induce DNA damage and trigger cell cycle arrest or cell death.Discussion: Our findings encourage future research focused on identifying redox-sensitive targets in the cell cycle machinery, potentially leading to new treatments for diseases with dysregulated cell proliferation.

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来源期刊
Redox Report
Redox Report 生物-生化与分子生物学
CiteScore
6.10
自引率
0.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.
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