代谢中枢控制中的神经酰胺。

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2025-01-01 Epub Date: 2024-07-06 DOI:10.1016/j.tem.2024.06.007

Miguel López, Carlos Diéguez, Manuel Tena-Sempere, Ismael González-García

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引用次数: 0

摘要

中枢神经酰胺通过影响下丘脑神经元来调节能量代谢。这使得神经酰胺能够整合瘦素、胃泌素、甲状腺激素或雌二醇等内分泌信号，并调节青春期的中枢控制。在这篇论坛文章中，我们将讨论最近的证据表明，特定的神经酰胺种类和神经元群参与了这些作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ceramides in the central control of metabolism.

Central ceramides regulate energy metabolism by impacting hypothalamic neurons. This allows ceramides to integrate endocrine signals - such as leptin, ghrelin, thyroid hormones, or estradiol - and to modulate the central control of puberty. In this forum article we discuss recent evidence suggesting that specific ceramide species and neuronal populations are involved in these effects.

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

期刊介绍： Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.

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