有自闭症家族史的婴儿在孩童中期自闭症兄弟姐妹复发。

IF 5.3 2区 医学 Q1 BEHAVIORAL SCIENCES Autism Research Pub Date : 2024-07-08 DOI:10.1002/aur.3182
Tessel Bazelmans, Rowan Arthur, Greg Pasco, Elizabeth Shephard, Bosiljka Milosavljevic, Jannath Begum Ali, Andrew Pickles, Mark H. Johnson, Emily J. H. Jones, Tony Charman, The BASIS/STAARS Team
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引用次数: 0

摘要

在前瞻性婴儿家族史研究中,自闭症兄弟姐妹在 3 岁时的复发率约为 20%,但系统性随访至儿童中期的情况却很少见。在人群和临床队列中,有些儿童直到学龄期或更晚才被发现患有自闭症。159 名有一个患有自闭症的哥哥姐姐的婴儿接受了 3 岁和童年中期(6 至 12 岁,平均 9 岁)的研究诊断评估。我们报告了自闭症兄弟姐妹在童年中期的复发率,并比较了较早和较晚被确认患有自闭症的婴儿,以及已经或尚未接受社区自闭症诊断的婴儿在童年中期和 3 岁时的发育和行为特征。该样本在儿童中期的自闭症复发率为 37.1%,95% CI [29.9%, 44.9%],男孩的复发率高于女孩。在儿童中期被诊断患有自闭症的儿童中,约有一半在 3 岁时没有得到诊断。后来,女孩被诊断患有自闭症的比例高于男孩。有些儿童在 3 岁时症状未达到阈值,而另一些儿童则是在早期症状基本典型的情况下被诊断出患有自闭症。基于社区临床诊断的兄弟姐妹复发率为 24.5%,95% CI [18.4%,31.9%]。那些也在社区确诊的患者往往年龄较大,适应功能较差,自闭症和注意力不集中症状较重。尽管存在单点研究的局限性、样本量不大以及可推广性的限制,但与报告3岁诊断结果的研究相比,有家族史的婴儿在儿童中期的自闭症兄弟姐妹复发率可能更高。研究结果对家庭和临床服务以及前瞻性家族史研究具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Mid-childhood autism sibling recurrence in infants with a family history of autism

Autism sibling recurrence in prospective infant family history studies is ~20% at 3 years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3 years and mid-childhood (6 to 12 years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3 years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3 years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3 years. Findings have implications for families and clinical services, and for prospective family history studies.

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来源期刊
Autism Research
Autism Research 医学-行为科学
CiteScore
8.00
自引率
8.50%
发文量
187
审稿时长
>12 weeks
期刊介绍: AUTISM RESEARCH will cover the developmental disorders known as Pervasive Developmental Disorders (or autism spectrum disorders – ASDs). The Journal focuses on basic genetic, neurobiological and psychological mechanisms and how these influence developmental processes in ASDs.
期刊最新文献
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