{"title":"在噬菌体编码的 CRISPR-Cas 系统中招募 Cas2/3 的另一种机制","authors":"","doi":"10.1038/s41589-024-01667-5","DOIUrl":null,"url":null,"abstract":"In type I-F CRISPR–Cas systems, Cas2/3 is typically recruited to the interference complex Cascade by Cas8f. We resolved the structures of the phage ICP1 CRISPR–Cas complexes and discovered a Cas2/3 recruitment mechanism distinct from that in other type I-F systems — recruitment by Cas1.","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":null,"pages":null},"PeriodicalIF":12.9000,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system\",\"authors\":\"\",\"doi\":\"10.1038/s41589-024-01667-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In type I-F CRISPR–Cas systems, Cas2/3 is typically recruited to the interference complex Cascade by Cas8f. We resolved the structures of the phage ICP1 CRISPR–Cas complexes and discovered a Cas2/3 recruitment mechanism distinct from that in other type I-F systems — recruitment by Cas1.\",\"PeriodicalId\":18832,\"journal\":{\"name\":\"Nature chemical biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":12.9000,\"publicationDate\":\"2024-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature chemical biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1038/s41589-024-01667-5\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature chemical biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41589-024-01667-5","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system
In type I-F CRISPR–Cas systems, Cas2/3 is typically recruited to the interference complex Cascade by Cas8f. We resolved the structures of the phage ICP1 CRISPR–Cas complexes and discovered a Cas2/3 recruitment mechanism distinct from that in other type I-F systems — recruitment by Cas1.
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