{"title":"通过伪三组分反应合成螺[色烯并[2,3-b]吡啶-3,4'-吡唑]衍生物的多样性。","authors":"Wenyan Zhou, Jiaman Lv and Cunde Wang*, ","doi":"10.1021/acs.joc.4c00959","DOIUrl":null,"url":null,"abstract":"<p >A novel one-pot pseudo-three-component reaction of 2-amino-4<i>H</i>-chromen-4-ones with 4-benzylidene-5-alkyl-2-aryl-2,4-dihydro-3<i>H</i>-pyrazol-3-ones was investigated for the synthesis of the spiro[chromeno[2,3-<i>b</i>]pyridine-3,4′-pyrazole] derivatives. This procedure involved Michael addition, elimination, and hetero-Diels–Alder sequences, affording a series of spiropyrazolone-chromeno[2,3-<i>b</i>]pyridines in good yields that possessed <i>cis</i> relationships between two aryl groups and the carbonyl of the pyrazolone unit.</p>","PeriodicalId":57,"journal":{"name":"The Journal of Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diversity-Oriented Synthesis of Spiro[chromeno[2,3-b]pyridine-3,4′-pyrazole] Derivatives via Pseudo-Three-Component Reactions\",\"authors\":\"Wenyan Zhou, Jiaman Lv and Cunde Wang*, \",\"doi\":\"10.1021/acs.joc.4c00959\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >A novel one-pot pseudo-three-component reaction of 2-amino-4<i>H</i>-chromen-4-ones with 4-benzylidene-5-alkyl-2-aryl-2,4-dihydro-3<i>H</i>-pyrazol-3-ones was investigated for the synthesis of the spiro[chromeno[2,3-<i>b</i>]pyridine-3,4′-pyrazole] derivatives. This procedure involved Michael addition, elimination, and hetero-Diels–Alder sequences, affording a series of spiropyrazolone-chromeno[2,3-<i>b</i>]pyridines in good yields that possessed <i>cis</i> relationships between two aryl groups and the carbonyl of the pyrazolone unit.</p>\",\"PeriodicalId\":57,\"journal\":{\"name\":\"The Journal of Organic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Organic Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.joc.4c00959\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Organic Chemistry","FirstCategoryId":"1","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.joc.4c00959","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Diversity-Oriented Synthesis of Spiro[chromeno[2,3-b]pyridine-3,4′-pyrazole] Derivatives via Pseudo-Three-Component Reactions
A novel one-pot pseudo-three-component reaction of 2-amino-4H-chromen-4-ones with 4-benzylidene-5-alkyl-2-aryl-2,4-dihydro-3H-pyrazol-3-ones was investigated for the synthesis of the spiro[chromeno[2,3-b]pyridine-3,4′-pyrazole] derivatives. This procedure involved Michael addition, elimination, and hetero-Diels–Alder sequences, affording a series of spiropyrazolone-chromeno[2,3-b]pyridines in good yields that possessed cis relationships between two aryl groups and the carbonyl of the pyrazolone unit.
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The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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