{"title":"艾滋病暴露前预防 (PREP) 对巴西圣保罗参考中心随访患者健康相关生活质量 (QOL) 的影响。","authors":"Michelle Kaoru Takada-de-Souza, Camila de Melo Picone, Vivian Iida Avelino-Silva, Angela Carvalho Freitas, Aluisio Cotrim Segurado","doi":"10.1016/j.clinsp.2024.100419","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>HIV Pre-Exposure Pophylaxis (PrEP) is provided free of charge by the Brazilian national health system. Though effective in preventing HIV infection, little is known about its impact on the health-related Quality of Life (QoL) of users.</p></div><div><h3>Objective</h3><p>The present study aimed at assessing the impact of PrEP on the QoL of its users.</p></div><div><h3>Methods</h3><p>Prospective cohort study with 114 HIV-negative participants aged 18 years or older. Participants' QoL was assessed before starting PrEP and after 7 months of use, using the self-responsive WHOQOL-bref questionnaire. Sociodemographic and behavioral aspects were described and the Wilcoxon signed-rank test with p ≤ 0.05 was considered statistically significant.</p></div><div><h3>Results</h3><p>Improvement was seen in QoL scores for the environment domain (p = 0.02), which addresses feeling of physical safety, access to information and health services, and participation in leisure activities. Furthermore, participants reported improved satisfaction with their sex life, when questioned about the social relationships domain. There was no statistically significant change in the global QoL score, in the global health score, in the physical and psychological domains, nor in the total score for the social relationships domain. As for their socio-demographic profile, most participants were white and highly educated young cisgender men who have sex with men. 76.3% had unprotected sex in the 3 months before starting PrEP. 60.5% had reported substance use: marijuana (42.1%), club drugs (35.1%), and poppers (20.2%).</p></div><div><h3>Conclusions</h3><p>This study unveiled that PrEP benefited our cohort beyond its effectiveness in preventing HIV infection, having improved environmental aspects of QoL and self-satisfaction with sex life.</p></div>","PeriodicalId":10472,"journal":{"name":"Clinics","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1807593224000966/pdfft?md5=665ef35b8f514ac0bdaa2a562965e3f9&pid=1-s2.0-S1807593224000966-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Impact of HIV pre-exposure prophylaxis (PREP) on health-related quality of life (QOL) of patients followed up at a reference center in São Paulo, Brazil\",\"authors\":\"Michelle Kaoru Takada-de-Souza, Camila de Melo Picone, Vivian Iida Avelino-Silva, Angela Carvalho Freitas, Aluisio Cotrim Segurado\",\"doi\":\"10.1016/j.clinsp.2024.100419\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>HIV Pre-Exposure Pophylaxis (PrEP) is provided free of charge by the Brazilian national health system. Though effective in preventing HIV infection, little is known about its impact on the health-related Quality of Life (QoL) of users.</p></div><div><h3>Objective</h3><p>The present study aimed at assessing the impact of PrEP on the QoL of its users.</p></div><div><h3>Methods</h3><p>Prospective cohort study with 114 HIV-negative participants aged 18 years or older. Participants' QoL was assessed before starting PrEP and after 7 months of use, using the self-responsive WHOQOL-bref questionnaire. Sociodemographic and behavioral aspects were described and the Wilcoxon signed-rank test with p ≤ 0.05 was considered statistically significant.</p></div><div><h3>Results</h3><p>Improvement was seen in QoL scores for the environment domain (p = 0.02), which addresses feeling of physical safety, access to information and health services, and participation in leisure activities. Furthermore, participants reported improved satisfaction with their sex life, when questioned about the social relationships domain. There was no statistically significant change in the global QoL score, in the global health score, in the physical and psychological domains, nor in the total score for the social relationships domain. As for their socio-demographic profile, most participants were white and highly educated young cisgender men who have sex with men. 76.3% had unprotected sex in the 3 months before starting PrEP. 60.5% had reported substance use: marijuana (42.1%), club drugs (35.1%), and poppers (20.2%).</p></div><div><h3>Conclusions</h3><p>This study unveiled that PrEP benefited our cohort beyond its effectiveness in preventing HIV infection, having improved environmental aspects of QoL and self-satisfaction with sex life.</p></div>\",\"PeriodicalId\":10472,\"journal\":{\"name\":\"Clinics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1807593224000966/pdfft?md5=665ef35b8f514ac0bdaa2a562965e3f9&pid=1-s2.0-S1807593224000966-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1807593224000966\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1807593224000966","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
背景:艾滋病毒暴露前预防疗法(PrEP)由巴西国家卫生系统免费提供。尽管 PrEP 能有效预防 HIV 感染,但人们对其对使用者健康相关生活质量(QoL)的影响知之甚少:本研究旨在评估 PrEP 对使用者生活质量的影响:前瞻性队列研究:114 名 18 岁或以上的 HIV 阴性参与者。在开始使用 PrEP 前和使用 7 个月后,使用自我响应式 WHOQOL-bref 问卷对参与者的 QoL 进行了评估。对社会人口学和行为学方面进行了描述,并进行了 Wilcoxon 符号秩检验,认为 p≤ 0.05 具有统计学意义:结果:环境领域的 QoL 分数有所提高(p = 0.02),该领域涉及身体安全感、信息和医疗服务的获取以及休闲活动的参与。此外,在被问及社会关系领域时,参与者对性生活的满意度也有所提高。总体 QoL 分数、总体健康分数、生理和心理领域以及社会关系领域的总分在统计上没有明显变化。在社会人口学特征方面,大多数参与者都是白人,受过高等教育的年轻男性同性恋者。76.3%的人在开始使用 PrEP 之前的 3 个月中发生过无保护措施的性行为。60.5%的人报告使用过药物:大麻(42.1%)、俱乐部毒品(35.1%)和兴奋剂(20.2%):这项研究表明,PrEP 不仅能有效预防艾滋病病毒感染,还能改善环境方面的 QoL 以及对性生活的自我满意度。
Impact of HIV pre-exposure prophylaxis (PREP) on health-related quality of life (QOL) of patients followed up at a reference center in São Paulo, Brazil
Background
HIV Pre-Exposure Pophylaxis (PrEP) is provided free of charge by the Brazilian national health system. Though effective in preventing HIV infection, little is known about its impact on the health-related Quality of Life (QoL) of users.
Objective
The present study aimed at assessing the impact of PrEP on the QoL of its users.
Methods
Prospective cohort study with 114 HIV-negative participants aged 18 years or older. Participants' QoL was assessed before starting PrEP and after 7 months of use, using the self-responsive WHOQOL-bref questionnaire. Sociodemographic and behavioral aspects were described and the Wilcoxon signed-rank test with p ≤ 0.05 was considered statistically significant.
Results
Improvement was seen in QoL scores for the environment domain (p = 0.02), which addresses feeling of physical safety, access to information and health services, and participation in leisure activities. Furthermore, participants reported improved satisfaction with their sex life, when questioned about the social relationships domain. There was no statistically significant change in the global QoL score, in the global health score, in the physical and psychological domains, nor in the total score for the social relationships domain. As for their socio-demographic profile, most participants were white and highly educated young cisgender men who have sex with men. 76.3% had unprotected sex in the 3 months before starting PrEP. 60.5% had reported substance use: marijuana (42.1%), club drugs (35.1%), and poppers (20.2%).
Conclusions
This study unveiled that PrEP benefited our cohort beyond its effectiveness in preventing HIV infection, having improved environmental aspects of QoL and self-satisfaction with sex life.
期刊介绍:
CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.