内脏脂肪与肥胖者内皮功能和亚临床动脉粥样硬化的关系。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2024-07-09 DOI:10.2478/rjim-2024-0024
Merve Polat Kose, Mehmet Emin Piskinpasa, Yalcin Hacioglu, Turgut Karabag
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引用次数: 0

摘要

引言在心血管系统中,肥胖会加速动脉粥样硬化的发展,诱发从青壮年时期就能发现的病理生理变化。内皮功能障碍是肥胖症最早出现的血管变化之一。在这项研究中,我们旨在确定无明显心血管疾病的肥胖症患者的内皮功能和颈动脉内膜中层厚度:研究对象为 112 名无明显心血管疾病和任何慢性疾病的肥胖症患者(BMI>30 kg/m2)(84 名女性,28 名男性,平均年龄(46.3±11.2)岁)和 49 名无疾病的健康人(33 名女性,16 名男性,平均年龄(44.6±10.2)岁)。所有患者都通过血流介导扩张(FMD)法和颈动脉内膜中层厚度(CIMT)检查了内皮功能。所有测量均由同一影像专家进行,取 3 次不同测量的平均值。除了体重指数和腰围外,还计算了内脏脂肪指数(VAI)和三叉神经质量指数(TPI):结果:与第 2 组相比,第 1 组通过肱动脉超声获得的 FMD 百分比明显较低,通过腹部超声和 CIMT 测量的内脏脂肪组织和肾周脂肪组织厚度明显较厚。FMD 与体重指数、内脏脂肪组织厚度、肾周脂肪组织厚度、腰围和臀围呈显著负相关,而颈动脉内膜厚度和 CIMT 与内脏脂肪组织厚度、肾周脂肪组织厚度、VAI、TPI 以及腰围和臀围呈显著相关:结论:与健康人相比,肥胖症患者的内皮功能受损,颈动脉内膜中层厚度增大。内皮功能受损与内脏和肾周脂肪堆积量成正比。反映内脏脂肪分布的参数(如 VAI 和 TPI)也与这些损伤有关。
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The relationship of visceral adiposity with endothelial functions and subclinical atherosclerosis in obese individuals.

Introduction: On the cardiovascular system, obesity accelerates atherosclerosis progression, inducing pathophysiological changes that are detectable already from young adults. Endothelial dysfunction is one of the earliest vascular alterations observed in obesity. In this study, we aimed to determine endothelial functions and carotid intima-media thickness in patients with obesity without overt cardiovascular disease.

Methods: The study was conducted with 112 individuals with obesity without overt cardiovascular disease and any chronical diseases (BMI>30 kg/m2) (84 female, 28 male, mean age: 46.3±11.2 years) and 49 healthy individuals with no diseases (33 female, 16 male, mean age: 44.6±10.2 years). All patients were examined for endothelial functions by the flow-mediated dilatation (FMD) method and carotid intima-media thicknesses (CIMT). All measurements were performed by the same imaging specialist, averaging 3 different measurements. In addition to the body mass index and waist circumference visceral adiposity index (VAI) and triponderal mass index (TPI) also calculated.

Results: The percentage of FMD obtained by brachial artery ultrasound was significantly lower, visceral adipose tissue, perirenal adipose tissue thicknesses measured by abdominal ultrasound and CIMT were significantly thicker in Group 1 compared to Group 2. FMD had a negative significant correlation with body mass index, visceral adipose tissue thickness, perirenal adipose tissue thickness, and waist and hip circumferences, and carotid intima-media thickness and CIMT had a significant correlation with visceral adipose tissue thickness, perirenal adipose tissue thickness, VAI, TPI and waist, hip circumferences.

Conclusion: Individuals with obesity have impaired endothelial functions and greater carotid intima-media thicknesses compared to healthy individuals. This impairment in endothelial functions is proportional to the amount of visceral and perirenal fat accumulation. Parameterss reflecting visceral fat distribution such as VAI and TPI are also related with these impairment.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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