{"title":"哮喘患者吸食电子烟后气道炎症的变化与呼吸力学的变化之间是否存在相关性？","authors":"Serafeim-Chrysovalantis Kotoulas, Kalliopi Domvri, Alexandros Tsantos, Ioanna Papagiouvanni, Anastasia Michailidou, Dionisios G Spyratos, Konstantinos Porpodis, Ioanna Grigoriou, Despina Papakosta, Athanasia Pataka","doi":"10.5662/wjm.v14.i2.89284","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Electronic cigarettes (ECs) have been promoted as alternatives to traditional cigarettes.</p><p><strong>Aim: </strong>To investigate ECs' effects on respiratory system, especially in patients with respiratory diseases.</p><p><strong>Methods: </strong>We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy smokers. All were subjucted to pulmonary function tests (PFTs), impulse oscillometry (IOS), fraction exhaled Nitric Oxide (FeNO), exhaled breathe condensate (EBC) and biomarker measurements before and after vaping one nicotine-containing EC.</p><p><strong>Results: </strong>The increase in FeNO 30 minutes after EC, reflecting airway inflammation, significantly correlated with increase of residual volume (RV), total lung capacity, respiratory impedance at 5 Hz (Z5Hz) and respiratory resistance at 5 and 20 Hz (R5Hz and R20Hz). No significant correlations were found between EBC biomarkers' changes and respiratory mechanics.</p><p><strong>Conclusion: </strong>This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.</p>","PeriodicalId":94271,"journal":{"name":"World journal of methodology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229872/pdf/","citationCount":"0","resultStr":"{\"title\":\"Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?\",\"authors\":\"Serafeim-Chrysovalantis Kotoulas, Kalliopi Domvri, Alexandros Tsantos, Ioanna Papagiouvanni, Anastasia Michailidou, Dionisios G Spyratos, Konstantinos Porpodis, Ioanna Grigoriou, Despina Papakosta, Athanasia Pataka\",\"doi\":\"10.5662/wjm.v14.i2.89284\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Electronic cigarettes (ECs) have been promoted as alternatives to traditional cigarettes.</p><p><strong>Aim: </strong>To investigate ECs' effects on respiratory system, especially in patients with respiratory diseases.</p><p><strong>Methods: </strong>We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy smokers. All were subjucted to pulmonary function tests (PFTs), impulse oscillometry (IOS), fraction exhaled Nitric Oxide (FeNO), exhaled breathe condensate (EBC) and biomarker measurements before and after vaping one nicotine-containing EC.</p><p><strong>Results: </strong>The increase in FeNO 30 minutes after EC, reflecting airway inflammation, significantly correlated with increase of residual volume (RV), total lung capacity, respiratory impedance at 5 Hz (Z5Hz) and respiratory resistance at 5 and 20 Hz (R5Hz and R20Hz). No significant correlations were found between EBC biomarkers' changes and respiratory mechanics.</p><p><strong>Conclusion: </strong>This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.</p>\",\"PeriodicalId\":94271,\"journal\":{\"name\":\"World journal of methodology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229872/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World journal of methodology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5662/wjm.v14.i2.89284\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of methodology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5662/wjm.v14.i2.89284","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?
Background: Electronic cigarettes (ECs) have been promoted as alternatives to traditional cigarettes.
Aim: To investigate ECs' effects on respiratory system, especially in patients with respiratory diseases.
Methods: We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy smokers. All were subjucted to pulmonary function tests (PFTs), impulse oscillometry (IOS), fraction exhaled Nitric Oxide (FeNO), exhaled breathe condensate (EBC) and biomarker measurements before and after vaping one nicotine-containing EC.
Results: The increase in FeNO 30 minutes after EC, reflecting airway inflammation, significantly correlated with increase of residual volume (RV), total lung capacity, respiratory impedance at 5 Hz (Z5Hz) and respiratory resistance at 5 and 20 Hz (R5Hz and R20Hz). No significant correlations were found between EBC biomarkers' changes and respiratory mechanics.
Conclusion: This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.
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