未发现关联:童年不良经历与澳大利亚老年人的认知障碍

James Lian, K. M. Kiely, B. L. Callaghan, R. Eramudugolla, M. Mortby, K. J. Anstey
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引用次数: 0

摘要

本研究旨在探讨童年逆境与老年人认知障碍之间的关系。方法我们分析了 "人格与全面健康(PATH)贯穿生命项目 "第 4 波的 1568 名 72-79 岁参与者(男 = 75.1,女 = 1.5,男性 = 52.6%)的数据。结果变量为是否患有轻度认知障碍(MCI)或痴呆症,通过临床验证的算法诊断标准确定。童年逆境采用 17 个项目的量表进行评估,涵盖贫困、忽视、身体虐待和辱骂等各种家庭逆境。通过累积分析、二分法(3 种逆境;3 种以上逆境)和潜类分析对逆境进行操作。结果我们的分析表明,在所有测试模型中,童年逆境与MCI或痴呆症之间没有显著的关联。结论与普遍的研究结果不同,本研究并不支持童年家庭逆境与晚年认知结果之间存在联系。这些结果表明,关于逆境和认知的研究结果喜忧参半,需要进一步研究。未来的研究应考虑潜在的中介和保护因素在这一复杂关系中的作用。
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No Association Found: Adverse Childhood Experiences and Cognitive Impairment in Older Australian Adults

Objective

This study aimed to investigate the relationship between childhood adversity and cognitive impairment in older adults.

Methods

We analysed data from 1568 participants aged 72–79 (M = 75.1, SD = 1.5, % male = 52.6%) from Wave 4 of the Personality and Total Health (PATH) Through Life Project. The outcome variable was the presence of mild cognitive impairment (MCI) or dementia, determined through a clinically validated algorithmic diagnostic criteria. Childhood adversity was assessed using a 17-item scale covering various domestic adversities such as poverty, neglect, physical abuse, and verbal abuse. Adversity was operationalised using cumulative analysis, dichotomisation (<3 adversities; 3+ adversities), and latent class analysis. Multiple logistic regressions were employed to estimate the association between childhood adversity and cognitive impairment, while controlling for covariates including education, gender, ethnicity, and APOE ε4 status.

Results

Our analyses revealed no significant association between childhood adversity and the presence of MCI or dementia across all tested models. Sensitivity analyses, exploring alternative scenarios, consistently failed to yield statistically significant findings.

Conclusion

In contrast to prevailing research findings, this study does not support a link between childhood domestic adversity and late-life cognitive outcomes. These results underscore the mixed results on adversity and cognition, highlighting the need for further research. Future investigations should consider the roles of potential mediating and protective factors within this complex relationship.

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来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
自引率
0.00%
发文量
0
期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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