髋部骨折后,医院组织因素与出院时开具抗骨质疏松药物以应对迫在眉睫的再骨折风险有关:一项记录链接研究。

IF 5.1 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Journal of Bone and Mineral Research Pub Date : 2024-08-21 DOI:10.1093/jbmr/zjae100
Rita Patel, Andrew Judge, Antony Johansen, Muhammad K Javaid, Xavier L Griffin, Tim Chesser, Jill Griffin, Elsa M R Marques, Yoav Ben-Shlomo, Celia L Gregson
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引用次数: 0

摘要

众所周知,髋部骨折患者面临着迫在眉睫的再骨折风险。他们复杂的多学科康复治疗需要包括预防跌倒和抗骨质疏松症药物(AOM),以防止此类骨折的发生。本研究旨在确定哪些医院层面的组织因素可预测髋部骨折后 AOM 的处方和再骨折风险。研究人员对英格兰和威尔士(2016-19年)178 757名年龄≥60岁的髋部骨折患者进行了为期1年的队列研究和随访。来自172家医院的患者入院数据集、国家髋部骨折数据库和死亡率数据与从18家医院组织报告中提取的71项指标相关联。多层次模型确定了与(i) AOM处方和(ii) 骨折(按ICD10编码)相关的组织因素,这些因素与患者的病例组合无关。患者平均(标清)82.7(8.6)岁,71%为女性,18%来自护理院。总体而言,有101 735人(57%)在入院时获得了AOM处方;50 354人(28%)在1年的随访期间死亡,12 240人(7%)再次骨折。有12个组织因素与AOM处方有关,例如,与传统护理模式相比,由老年矫形外科医生主导的护理(OR 4.65 [95%CI:2.25-9.59]);在为所有患者提供常规骨健康评估的医院中,AOM处方的可能性要高9%(95%CI:6%-13%)。发生再骨折的时间中位数为126天(IQR为59-234)。八项组织因素与骨折风险相关;在入院 72 小时内为所有患者提供骨科评估的医院,骨折风险降低 18% (95%CI:2-31%);提供周末物理治疗的医院,骨折风险降低 8% (95%CI:3-14%);职业治疗师参加临床治理会议的医院,骨折风险降低 7% (95%CI:2-12%)。延迟启动出院后社区康复与高出 15%(95%CI:3-29%)的再骨折风险有关。这些新颖的全国性研究结果凸显了老年骨科医生、物理治疗师和职业治疗师参与髋部骨折后二次骨折预防的重要性;髋部骨折后12个月内骨折风险明显降低。
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Following hip fracture, hospital organizational factors associated with prescription of anti-osteoporosis medication on discharge, to address imminent refracture risk: a record-linkage study.

Patients who sustain a hip fracture are known to be at imminent refracture risk. Their complex multidisciplinary rehabilitation needs to include falls prevention and anti-osteoporosis medication (AOM) to prevent such fractures. This study aimed to determine which hospital-level organizational factors predict prescription of post-hip fracture AOM and refracture risk. A cohort of 178 757 patients aged ≥60 yr who sustained a hip fracture in England and Wales (2016-2019) was examined and followed for 1 yr. Patient-level hospital admission datasets from 172 hospitals, the National Hip Fracture Database, and mortality data were linked to 71 metrics extracted from 18 hospital-level organizational reports. Multilevel models determined organizational factors, independent of patient case-mix, associated with (1) AOM prescription and (2) refracture (by ICD10 coding). Patients were mean (SD) 82.7 (8.6) yr old, 71% female, with 18% admitted from care homes. Overall, 101 735 (57%) were prescribed AOM during admission, while 50 354 (28%) died during 1-yr follow-up, 12 240 (7%) refractured. Twelve organizational factors were associated with AOM prescription, for example, orthogeriatrician-led care compared to traditional care models (odds ratio [OR] 4.65 [95% CI, 2.25-9.59]); AOM was 9% (95% CI, 6%-13%) more likely to be prescribed in hospitals providing routine bone health assessment to all patients. Refracture occurred at median 126 d (IQR 59-234). Eight organizational factors were associated with refracture risk; hospitals providing orthogeriatrician assessment to all patients within 72 h of admission had an 18% (95% CI, 2%-31%) lower refracture risk, weekend physiotherapy provision had an 8% (95% CI, 3%-14%) lower risk, and where occupational therapists attended clinical governance meetings, a 7% (95% CI, 2%-12%) lower risk. Delays initiating post-discharge community rehabilitation were associated with a 15% (95% CI, 3%-29%) greater refracture risk. These novel, national findings highlight the importance of orthogeriatrician, physiotherapist, and occupational therapist involvement in secondary fracture prevention post hip fracture; notably, fracture risk reductions were seen within 12 mo of hip fracture.

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来源期刊
Journal of Bone and Mineral Research
Journal of Bone and Mineral Research 医学-内分泌学与代谢
CiteScore
11.30
自引率
6.50%
发文量
257
审稿时长
2 months
期刊介绍: The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.
期刊最新文献
The Quantification of Bone Mineral Density Using Photon Counting Computed Tomography and its Implications for Detecting Bone Remodelling. 24-Hour Activity Composition is Associated with Lower Fall and Fracture Risk in Older Men. A quasi-experimental study about shared decision-making and motivational interviewing on patients with a recent fracture attending a fracture liaison services. Atypical fractures at non-classical sites associated with anti-resorptive therapy: A Systematic Review. Epidural Steroid Injections and Fracture Incidence Among Older Individuals with Radiculopathy.
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