炎性细胞死亡--泛凋亡对健康和疾病的影响。

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL Archives of Pharmacal Research Pub Date : 2024-07-10 DOI:10.1007/s12272-024-01506-0
Hyun Bae, Yeonseo Jang, Rajendra Karki, Joo-Hui Han
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引用次数: 0

摘要

热凋亡、细胞凋亡和坏死等调节性细胞死亡(RCD)途径对于维持机体平衡、抵御病原体和清除可能导致癌症等疾病的异常细胞至关重要。虽然这些途径通过不同的机制运作,但最近的遗传学和药理学研究表明,它们可以相互作用和影响。细胞凋亡"(PANoptosis)的概念已经出现,强调了热凋亡、细胞凋亡和坏死之间的相互作用,尤其是在细胞对感染的反应过程中。本文简要概述了 "泛凋亡 "及其分子机制,探讨了其在各种疾病中的意义。综述侧重于不同 RCD 通路之间的广泛相互作用,强调了 PANoptosis 在感染、细胞因子风暴、炎症性疾病和癌症中的作用。了解 PANoptosis 对开发治疗感染、无菌性炎症和癌症的新方法至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Implications of inflammatory cell death-PANoptosis in health and disease

Regulated cell death (RCD) pathways, such as pyroptosis, apoptosis, and necroptosis, are essential for maintaining the body’s balance, defending against pathogens, and eliminating abnormal cells that could lead to diseases like cancer. Although these pathways operate through distinct mechanisms, recent genetic and pharmacological studies have shown that they can interact and influence each other. The concept of “PANoptosis” has emerged, highlighting the interplay between pyroptosis, apoptosis, and necroptosis, especially during cellular responses to infections. This article provides a concise overview of PANoptosis and its molecular mechanisms, exploring its implications in various diseases. The review focuses on the extensive interactions among different RCD pathways, emphasizing the role of PANoptosis in infections, cytokine storms, inflammatory diseases, and cancer. Understanding PANoptosis is crucial for developing novel treatments for conditions involving infections, sterile inflammations, and cancer.

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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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