评估卢戈尔溶液对磷化铝(米粒)中毒大鼠的保护作用。

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Toxicology Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI:10.1007/s12012-024-09890-1
Zeinab Vafaeipour, Mohsen Imenshahidi, Amir Hooshang Mohammadpour, Seyed Mohammad Taghdisi, Noor Mohammad Danesh, Mohammad Moshiri, Amir Hossein Jafarian, Khalil Abnous
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引用次数: 0

摘要

磷化铝(AlP)是大米药片(一种杀虫剂)的主要成分,接触胃酸后会产生磷化氢气体(PH3)。PH3 中毒的最主要症状包括嗜睡、心动过速、低血压和心脏休克。研究表明,碘可与 PH3 发生化学反应,本研究的目的是调查鲁戈尔溶液对米饭片中毒的保护作用。本研究选择了五种剂量(12、15、21、23 和 25 毫克/千克)的 AlP,以计算其致死剂量(LD50)。然后,将大鼠分为 4 组:AlP组、Lugol组、AlP + Lugol组和杏仁油组(作为对照组)。4 小时后,记录血压和心电图(ECG),采集血液样本进行生化测试,然后取出肝、肺、肾、心和脑组织进行组织病理学检查。血压结果显示无明显变化(P > 0.05)。在心电图中,AlP + Lugol 组的 PR 间期显著下降(P 2+),与 AlP 组相比,AlP + Lugol 组的肌酐、ALP、Mg2+ 和 K+ 显著下降(P 3+)。
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Evaluation of the Protective Effects of Lugol's Solution in Rats Poisoned with Aluminum Phosphide (Rice Tablets).

Aluminum phosphide (AlP) is the main component of rice tablets (a pesticide), which produces phosphine gas (PH3) when exposed to stomach acid. The most important symptoms of PH3 toxicity include, lethargy, tachycardia, hypotension, and cardiac shock. It was shown that Iodine can chemically react with PH3, and the purpose of this study is to investigate the protective effects of Lugol solution in poisoning with rice tablets. Five doses (12, 15, 21, 23, and 25 mg/kg) of AlP were selected, for calculating its lethal dose (LD50). Then, the rats were divided into 4 groups: AlP, Lugol, AlP + Lugol, and Almond oil (as a control). After 4 h, the blood pressure and electrocardiogram (ECG) were recorded, and blood samples were obtained for biochemical tests, then liver, lung, kidney, heart, and brain tissues were removed for histopathological examination. The results of the blood pressure showed no significant changes (P > 0.05). In ECG, the PR interval showed a significant decrease in the AlP + Lugol group (P < 0.05). In biochemical tests, LDH, Ca2+, Creatinine, ALP, Mg2+, and K+ represented significant decreases in AlP + Lugol compared to the AlP group (P < 0.05). Also, the administration of Lugol's solution to AlP-poisoned rats resulted in a significant decrease in malondialdehyde levels and a significant increase in catalase activity (P < 0.05). Histopathological evaluation indicates that Lugol improves changes in the lungs, kidneys, brain, and heart. Our results showed that the Lugol solution could reduce tissue damage and oxidative stress in AlP-poisoned rats. We assume that the positive effects of Lugol on pulmonary and cardiac tissues are due to its ability to react directly with PH3.

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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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