从同时使用布林佐胺和溴莫尼定改用布林佐胺/溴莫尼定固定剂量复方制剂后,角膜上皮损伤有所改善。

IF 2.1 3区 医学 Q2 OPHTHALMOLOGY Japanese Journal of Ophthalmology Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI:10.1007/s10384-024-01088-w
Yuko Maruyama, Yoko Ikeda, Kengo Yoshii, Kazuhiko Mori, Morio Ueno, Shigeru Kinoshita, Chie Sotozono
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引用次数: 0

摘要

目的:评估从同时使用1%布林佐胺(BZM)和0.1%溴莫尼定(BMD)改用BZM/BMD固定剂量复方制剂(BBFC)减少角膜上皮损伤的效果:研究设计:回顾性队列研究:本研究涉及 52 名青光眼患者(26 名女性,26 名男性;平均年龄:67.0 ± 14.0 岁)的 52 只眼睛,这些患者在从同时使用 BZM 和 BMD 转为使用 BBFC 后接受了 3 个多月的随访。浅层点状角膜炎(SPK)根据美国国立眼科研究所的分类法通过荧光素染色进行评估,角膜分为 5 个区域:中央、上部、鼻部、颞部和下部。SPK密度分为0级(无SPK)、1级(单独的SPK)、2级(中等密度的SPK)和3级(病变重叠的高密度SPK)。然后使用Wilcoxon符号秩检验比较转用BBFC前(pre-BBFC)和转用BBFC后3个月(post-BBFC)的SPK评分和眼压(IOP):BBFC前和BBFC后的平均眼压分别为12.4±2.5和12.4±2.7 mmHg,因此说明转换前后的眼压无显著差异(P = 0.924),中心、上、鼻、颞、下的平均SPK评分分别为0.06±0.24、0.04±0.19、0.52±0.67、0.15±0.36、0.92±0.74,和 0.04±0.19、0.02±0.14、0.37±0.56、0.04±0.19、0.75±0.62,由此可以清楚地看出,与 BBFC 前相比,BBFC 后鼻部、颞部和下部的 SPK 得分显著降低(p 结论:BBFC 后鼻部、颞部和下部的 SPK 得分显著降低:我们的研究结果表明,与同时使用 BZM 和 BMD 相比,BBFC 能有效减少角膜上皮损伤。
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Improvement of corneal epithelial damage after switching from the concomitant use of brinzolamide and brimonidine to a brinzolamide/brimonidine fixed-dose combination.

Purpose: To assess the effectiveness of switching from the concomitant use of brinzolamide 1% (BZM) and brimonidine 0.1% (BMD) to a BZM/BMD fixed-dose combination (BBFC) for the reduction of corneal epithelial damage.

Study design: Retrospective cohort study.

Methods: This study involved 52 eyes of 52 glaucoma patients (26 women, 26 men; mean age: 67.0 ± 14.0 years) followed for more than 3 months after being switched from concomitant BZM and BMD to BBFC. Superficial punctate keratitis (SPK) was assessed by fluorescein staining according to the National Eye Institute classification, with the cornea divided into 5 areas: center, superior, nasal, temporal, and inferior. SPK density was graded as 0 (no SPK), 1 (separate SPK), 2 (moderately dense SPK), and 3 (high SPK with overlapping lesions). SPK scores and intraocular pressure (IOP) at pre switching to BBFC (pre-BBFC) and at 3-months post switching to BBFC (post-BBFC) were then compared using the Wilcoxon signed-rank test.

Results: At pre-BBFC and post-BBFC, respectively, mean IOP was 12.4 ± 2.5 and 12.4 ± 2.7 mmHg, thus illustrating no significant difference in IOP between pre and post switch (p = 0.924), and the mean SPK score for center, superior, nasal, temporal, and inferior was 0.06 ± 0.24, 0.04 ± 0.19, 0.52 ± 0.67, 0.15 ± 0.36, and 0.92 ± 0.74, and 0.04 ± 0.19, 0.02 ± 0.14, 0.37 ± 0.56, 0.04 ± 0.19, and 0.75 ± 0.62, thus clearly showing a significant reduction in SPK scores for the nasal, temporal, and inferior areas at post-BBFC compared to those at pre-BBFC (p < 0.05).

Conclusion: Our findings reveal that compared with the concomitant use of BZM and BMD, BBFC is effective in reducing corneal epithelial damage.

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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
65
审稿时长
6-12 weeks
期刊介绍: The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.
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