Renata Kelly da Palma, Kátia De Angelis, Guilherme Lemos Shimojo, Marina Rascio Henriques Dutra, Camila Paixão Dos Santos, Nathalia Bernardes, Andressa Bolsoni-Lopes, Rui Curi, João Lucas Gomes, Edilamar Menezes Oliveira, Maria Claudia Irigoyen, Christiane Malfitano
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引用次数: 0
摘要
众所周知,绝经后心脏代谢功能障碍会逐渐加剧,而久坐不动的生活方式会加重这种状况。因此,我们比较了绝经前和卵巢切除术(OVX)后有氧运动训练对绝经实验模型大鼠代谢、血液动力学和自主神经参数的影响。雌性大鼠分为 4 组:对照组(C)、静坐 OVX 组(SO)、训练 OVX 组(TO)和先前训练 OVX 组(PTO)。PTO组在OVX四周前和八周后进行训练,TO组仅在OVX后在运动跑步机上进行训练。对自律神经调节进行评估,取出脂肪组织(WAT),称重并评估脂肪分解情况。分析了比目鱼肌中柠檬酸合成酶的活性。与 SO 相比,训练组防止了 BRS 的损害;然而,与 SO 相比,只有 PTO 减少了脉冲间隔的低频带。与其他组相比,PTO 减少了 WAT 的重量;PTO 的脂肪分解与 C 相似。总之,这项研究表明,应建议在绝经前模型中进行运动训练,以预防绝经引起的心脏代谢和自律神经的有害影响。
Mitigation of Subsequent Ovariectomy Responses through Prior Exercise Training in Rats.
It is well known that cardiometabolic dysfunction gradually increases after menopause, and the sedentary lifestyle can aggravate this condition. Therefore, we compared the effects of aerobic exercise training during the premenopausal period and after ovariectomy (OVX) on metabolic, hemodynamic, and autonomic parameters in an experimental rat model of menopause. The female rats were divided into four groups: control (C), sedentary OVX (SO), trained OVX (TO), and previously trained OVX (PTO). The PTO group was trained for 4 weeks prior to+8 weeks after OVX, and the TO group trained only after OVX on a motor treadmill. Autonomic modulation was evaluated, white adipose tissue (WAT) was removed and weighed, and lipolysis was assessed. The citrate synthase activity in the soleus muscle was analyzed. The trained groups prevented the impairment of baroreceptor reflex sensitivity in relation to SO; however, only PTO reduced the low-frequency band of the pulse interval compared to SO. PTO reduced the weight of WAT compared to the other groups; lipolysis in PTO was similar to that in C. PTO preserved muscle metabolic injury in all types of fibers analyzed. In conclusion, this study suggests that exercise training should be recommended in a premenopausal model to prevent cardiometabolic and autonomic menopause-induced deleterious effects.
期刊介绍:
The IJSM provides a forum for the publication of papers dealing with both basic and applied information that advance the field of sports medicine and exercise science, and offer a better understanding of biomedicine. The journal publishes original papers, reviews, short communications, and letters to the Editors.