先进药物载体脂质体:从基本原理到制药应用。

IF 3 4区 医学 Q2 CHEMISTRY, APPLIED Journal of microencapsulation Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI:10.1080/02652048.2024.2376116
Huma Hameed, Mahtab Ahmad Khan, Ana Cláudia Paiva-Santos, Saleha Faheem, Aleena Khalid, Muhammad Sohaib Majid, Aiman Adnan, Fizza Rana
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引用次数: 0

摘要

目的:文献中描述了大约 24 种不同的脂质囊泡,它们与脂质体等囊泡系统相似。类似脂质体的结构是由某些两亲性脂质与适当的稳定剂结合形成的。自发现和分类以来,自组装脂质体类结构作为活性药物输送载体吸引了研究人员的好奇心:这项综合研究包括使用 PubMed、ScienceDirect 和 Google Scholar 等电子数据库进行深入的文献检索,重点是 2024 年之前文献中讨论的有关脂质体和类脂质体结构的研究、其大小、优点、缺点、制备方法、表征和药物应用:结果:药用脂质体、立方脂质体、乙脂质体、转乙脂质体和基因体都是类似脂质体的结构,因其体积小、装载量大、易于吸收和能够治疗炎症性疾病而最具潜力。基因体因其对 DNA/基因运输的亲和力而具有未来性,这也是当今治疗的一个重点领域:本综述将对所有类脂质体结构的组成、制备程序、药物封装技术、药物负载、释放机制和相关应用进行批判性分析,强调它们与其他载体和传统载体相比具有更高的功效,为医药行业探索新型给药系统铺平了道路。
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Liposomes like advanced drug carriers: from fundamentals to pharmaceutical applications.

Aims: There are around 24 distinct lipid vesicles described in the literature that are similar to vesicular systems such as liposomes. Liposome-like structures are formed by combining certain amphiphilic lipids with a suitable stabiliser. Since their discovery and classification, self-assembled liposome-like structures as active drug delivery vehicles captured researchers' curiosity.

Methodology: This comprehensive study included an in-depth literature search using electronic databases such as PubMed, ScienceDirect and Google Scholar, focusing on studies on liposome and liposomes like structure, discussed in literature till 2024, their sizes, benefits, drawback, method of preparation, characterisation and pharmaceutical applications.

Results: Pharmacosomes, cubosomes, ethosomes, transethosomes, and genosomes, all liposome-like structures, have the most potential due to their smaller size with high loading capacity, ease of absorption, and ability to treat inflammatory illnesses. Genosomes are futuristic because of its affinity for DNA/gene transport, which is an area of focus in today's treatments.

Conclusion: This review will critically analyse the composition, preparation procedures, drug encapsulating technologies, drug loading, release mechanism, and related applications of all liposome-like structures, highlighting their potential benefits with enhanced efficacy over each other and over traditional carriers by paving the way for exploring novel drug delivery systems in the Pharma industry.

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来源期刊
Journal of microencapsulation
Journal of microencapsulation 工程技术-工程:化工
CiteScore
6.30
自引率
2.60%
发文量
39
审稿时长
3 months
期刊介绍: The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.
期刊最新文献
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