基线毛细血管镜没有提供微血管变化的证据来预测长 COVID 综合征。

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Bratislava Medical Journal-Bratislavske Lekarske Listy Pub Date : 2024-01-01 DOI:10.4149/BLL_2024_77
Bahar Ozdemir Ulusoy, Hakan Babaoglu, Berkan Armagan Adalet Aypak, Esragul Akinci, Orhan Kucuksahin, Ahmet Omma Sukran Erten, Abdulsamet Erden
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引用次数: 0

摘要

背景:长期 COVID 指的是急性 COVID-19 感染发病后至少持续 4 周的各种症状。"微血栓/微血管病 "是一种潜在的前沿理论。甲襞毛细血管镜检查是一种用于评估微血管的无创方法。在这项研究中,我们旨在比较长COVID综合征患者和非长COVID综合征患者的基线特征和毛细血管镜检查结果:记录了 53 名 SARS-CoV-2 检测呈阳性的患者的基线临床特征。在确诊 COVID-19 时,患者接受了甲皱毛细血管镜检查。一年后,对患者的长期 COVID 症状进行重新筛查。对患有和未患有长COVID综合征的患者在基线特征和毛细血管镜检查结果方面进行了比较:结果:有 35 人(66%)患有长钩脉综合征。与长COVID相关的最常见症状是疲劳(43.4%)、肌痛(34%)、关节痛(20.8%)和呼吸困难(20.8%)。共有 22 名患者(41.5%)的毛细血管镜检查结果异常。与其他基线特征一样,毛细血管镜检查结果异常的患者比例(40% vs 44%,P=0.76)在患有和未患有长COVID综合征的患者中相似:结论:微血管病变和微血栓性血管损伤是这方面讨论的最有力的假说之一。结论:微血管病变和微血栓性血管损伤是这方面讨论的最有力的假说之一。我们的研究结果可能表明,驱动长 COVID 综合征的病理生理机制的因素可能是基线微血管病变,而不是尚未被充分理解的微血管病变(参考文献 35,表 2)。
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Baseline capillaroscopy provides no evidence of microvascular changes to predict long-COVID syndrome.

Background: Long-COVID refers to a variety of symptoms that continue for at least 4 weeks following the onset of acute COVID-19 infection. "Microclots/microvasculopathy" is a potential cutting-edge theory. Nailfold capillaroscopy is a non-invasive method used to assess microvascularity. In this study, we aimed to compare baseline characteristics and capillaroscopic findings of patients with and without long-COVID syndrome.

Methods: Baseline clinical characteristics of 53 patients who tested positive for SARS-CoV-2 were recorded. At the time of COVID-19 diagnosis, patients underwent nailfold capillaroscopy. One year later, patients were rescreened for long-COVID symptoms. Comparisons were made between patients with and without long-COVID syndrome in terms of their baseline characteristics and capillaroscopic findings.

Results: There were 35 individuals (66%) with long-COVID syndrome. The most common symptoms related to long-COVID were fatigue (43.4%), myalgia (34%), arthralgia (20.8%), dyspnea (20.8%). In total, 22 patients (41.5%) had abnormal capillaroscopy findings. Like other baseline characteristics, the proportion of patients with abnormal capillaroscopic findings (40% vs 44%, p=0.76) was similar between patients with and without long-COVID syndrome.

Conclusion: Microvasculopathy and microthrombotic vascular damage are among the strongest hypotheses discussed in this regard. Our results may suggest that factors, rather than baseline microvasculopathy, may drive pathophysiological mechanism underlying the poorly understood long-COVID syndrome (Tab. 2, Ref. 35).

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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
185
审稿时长
3-8 weeks
期刊介绍: The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.
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